Molecular epidemiology of tuberculosis among HIV-infected persons in Switzerland: a countrywide 9-year cohort study. Swiss HIV Cohort Study

Détails

ID Serval
serval:BIB_DEA1ABD788AD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Molecular epidemiology of tuberculosis among HIV-infected persons in Switzerland: a countrywide 9-year cohort study. Swiss HIV Cohort Study
Périodique
Infection
Auteur(s)
Sudre  P., Pfyffer  G. E., Bodmer  T., Prod'hom  G., Furrer  H., Bassetti  S., Bernasconi  E., Matter  L., Telenti  A., Strassle  A., Jacques  J. P., Weber  R.
ISSN
0300-8126 (Print)
Statut éditorial
Publié
Date de publication
12/1999
Volume
27
Numéro
6
Pages
323-30
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Nov-Dec
Résumé
We investigated tuberculosis transmission during a nine-year period (1988-1996) in a countrywide community-based cohort of HIV-infected persons in Switzerland (the Swiss HIV Cohort Study [SHCS]). We estimated the proportion of tuberculosis cases due to reinfection and relapse, and assessed factors which may increase the risk of tuberculosis transmission. HIV-infected persons were followed prospectively and molecular fingerprinting with insertion sequence (IS) 6110, 36-bp direct repeat, and IS6110-PCR was used to determine M. tuberculosis case clustering. Out of 7999 SHCS participants, 267 persons developed tuberculosis. 158 M. tuberculosis isolates from 138 patients were available for study. Molecular analysis identified 33 (24%) episodes of tuberculosis associated with 12 clusters including 2 to 8 patients. Two patients experienced reinfection, and nine had a relapse. Detailed contact investigation identified definite or possible epidemiological links between 21 of 33 cluster patients (64%). Multivariate logistic regression analysis did not identify any risk marker significantly associated with clustering. During a nine-year period, one fourth of tuberculosis cases were grouped in clusters within a selection of 138 HIV-infected patients. This may represent the lowest estimation of recently acquired tuberculosis infection. There were no large institutional or community outbreaks among HIV-infected participants of the Swiss HIV Cohort Study.
Mots-clé
AIDS-Related Opportunistic Infections/epidemiology/transmission Adult DNA, Bacterial/genetics Female HIV Infections/*microbiology Humans Male Mycobacterium tuberculosis/*genetics Polymorphism, Restriction Fragment Length Prospective Studies Risk Factors Switzerland/epidemiology Tuberculosis/*epidemiology/*transmission
Pubmed
Web of science
Création de la notice
25/01/2008 15:46
Dernière modification de la notice
20/08/2019 17:03
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