Hippocampus-dependent learning is associated with adult neurogenesis in MRL/MpJ mice.

Détails

ID Serval
serval:BIB_DE51DE0B1E4F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Hippocampus-dependent learning is associated with adult neurogenesis in MRL/MpJ mice.
Périodique
Hippocampus
Auteur(s)
Thuret S., Toni N., Aigner S., Yeo G.W., Gage F.H.
ISSN
1098-1063[electronic]
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
19
Numéro
7
Pages
658-669
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
The hippocampus is involved in declarative memory and produces new neurons throughout adulthood. Numerous experiments have been aimed at testing the possibility that adult neurogenesis is required for learning and memory. However, progress has been encumbered by the fact that abating adult neurogenesis usually affects other biological processes, confounding the interpretation of such experiments. In an effort to circumvent this problem, we used a reverse approach to test the role of neurogenesis in hippocampus-dependent learning, exploiting the low levels of adult neurogenesis in the MRL/MpJ strain of mice compared with other mouse strains. We observed that adult MRL/MpJ mice produce 75% fewer new neurons in the dentate gyrus than age-matched C57BL/6 mice. Learning-induced synaptic remodeling, spatial learning, and visual recognition learning were reduced in MRL/MpJ mice compared with C57BL/6 mice. When MRL/MpJ mice were allowed unlimited access to running wheels, neurogenesis along with spatial learning and visual recognition learning were increased to levels comparable to those in running C57BL/6 mice. Together, these results suggest that adult neurogenesis is correlated with spatial learning and visual recognition learning, possibly by modulating morphological plasticity in the dentate gyrus.
Mots-clé
Adult Stem Cells/physiology, Animals, Dentate Gyrus/physiology, Dentate Gyrus/ultrastructure, Female, Hippocampus/physiology, Hippocampus/ultrastructure, Learning/physiology, Maze Learning/physiology, Mice, Mice, Inbred C57BL, Mice, Mutant Strains, Neurogenesis, Neurons/physiology, Neurons/ultrastructure, Pattern Recognition, Visual/physiology, Physical Conditioning, Animal/physiology, Space Perception/physiology, Synapses/physiology, Synapses/ultrastructure, Time Factors
Pubmed
Web of science
Création de la notice
22/01/2010 8:42
Dernière modification de la notice
20/08/2019 17:02
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