The Aedes aegypti genome: a comparative perspective.

Détails

Ressource 1Télécharger: Aedes_Genomics.pdf (687.21 [Ko])
Etat: Public
Version: Author's accepted manuscript
Licence: Non spécifiée
ID Serval
serval:BIB_DE0894A70E66
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
The Aedes aegypti genome: a comparative perspective.
Périodique
Insect Molecular Biology
Auteur⸱e⸱s
Waterhouse R.M., Wyder S., Zdobnov E.M.
ISSN
1365-2583 (Electronic)
ISSN-L
0962-1075
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
17
Numéro
1
Pages
1-8
Langue
anglais
Résumé
The sequencing of the second mosquito genome, Aedes aegypti, in addition to Anopheles gambiae, is a major milestone that will drive molecular-level and genome-wide high-throughput studies of not only these but also other mosquito vectors of human pathogens. Here we overview the ancestry of the mosquito genes, list the major expansions of gene families that may relate to species adaptation processes, as exemplified by CYP9 cytochrome P450 genes, and discuss the conservation of chromosomal gene arrangements among the two mosquitoes and fruit fly. Many more invertebrate genomes are expected to be sequenced in the near future, including additional vectors of human pathogens (see http://www.vectorbase.org), and further comparative analyses will become increasingly refined and informative, hopefully improving our understanding of the genetic basis of phenotypical differences among these species, their vectorial capacity, and ultimately leading to the development of novel disease control strategies.
Mots-clé
comparative genomics, gene family, insect, mosquito, synteny, vector
Pubmed
Web of science
Création de la notice
20/09/2017 10:26
Dernière modification de la notice
09/04/2022 17:35
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