Dietary restriction affects lifespan but not cognitive aging in Drosophila melanogaster.

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_DDE59B41EFBD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Dietary restriction affects lifespan but not cognitive aging in Drosophila melanogaster.
Périodique
Aging Cell
Auteur(s)
Burger J.M.S., Buechel S.D., Kawecki T.J.
ISSN
1474-9726[electronic], 1474-9718[linking]
Statut éditorial
Publié
Date de publication
2010
Peer-reviewed
Oui
Volume
9
Numéro
3
Pages
327-335
Langue
anglais
Résumé
Summary Dietary restriction extends lifespan in a wide variety of animals, including Drosophila, but its relationship to functional and cognitive aging is unclear. Here, we study the effects of dietary yeast content on fly performance in an aversive learning task (association between odor and mechanical shock). Learning performance declined at old age, but 50-day-old dietary-restricted flies learned as poorly as equal-aged flies maintained on yeast-rich diet, even though the former lived on average 9 days (14%) longer. Furthermore, at the middle age of 21 days, flies on low-yeast diets showed poorer short-term (5 min) memory than flies on rich diet. In contrast, dietary restriction enhanced 60-min memory of young (5 days old) flies. Thus, while dietary restriction had complex effects on learning performance in young to middle-aged flies, it did not attenuate aging-related decline of aversive learning performance. These results are consistent with the hypothesis that, in Drosophila, dietary restriction reduces mortality and thus leads to lifespan extension, but does not affect the rate with which somatic damage relevant for cognitive performance accumulates with age.
Mots-clé
caloric restriction, learning, memory, functional aging, age-related memory impairment, Drosophila
Pubmed
Web of science
Création de la notice
05/05/2010 15:15
Dernière modification de la notice
20/08/2019 17:02
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