The negative predictive value of D-dimer on the risk of recurrent venous thromboembolism in patients with multiple previous events: a prospective cohort study (the PROLONG PLUS study).

Détails

ID Serval
serval:BIB_DDE2FBEAEAE9
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Lettre (letter): communication adressée à l'éditeur.
Collection
Publications
Titre
The negative predictive value of D-dimer on the risk of recurrent venous thromboembolism in patients with multiple previous events: a prospective cohort study (the PROLONG PLUS study).
Périodique
American Journal of Hematology
Auteur(s)
Ageno W., Cosmi B., Ghirarduzzi A., Santoro R., Bucherini E., Poli D., Prisco D., Alatri A., Pengo V., Galli L., Dentali F., Palareti G.
ISSN
1096-8652 (Electronic)
ISSN-L
0361-8609
Statut éditorial
Publié
Date de publication
2012
Volume
87
Numéro
7
Pages
713-715
Langue
anglais
Notes
Publication types: Clinical Trial ; Journal ArticlePublication Status: ppublish
Résumé
The optimal duration of anticoagulation after recurrent venous thromboembolism(VTE) is poorly established [1,2]. Recent studies suggested that D-dimer may identify patients at low risk of recurrence after a first VTE [3,4]. In a pilot, prospective, cohort study we aimed to assess the negative predictive value of D-dimer in patients with recurrent VTE. Patients with negative D-dimer while on treatment stopped anti coagulation and underwent repeated testing after 7, 15, and 30 days; treatment was resumed if D-dimer turned positive and permanently stopped if it remained negative. The study was interrupted after the enrolment of 75 patients. At that time, treating physicians decided treatment resumption in 12.2% of the patients, but the majority of events were distal or superficial vein thromboses. The rate of objectively documented recurrent proximal deep vein thrombosis (DVT) and/or pulmonary embolism (PE) was 2.56% (95% CI 0.13, 15.07%) in the 39 patients with persistently negative D-dimer at 30 days, for an annual incidence of VTE of 5.65 events/100 patient/years. These preliminary findings suggest that negative D-dimer may identify patients with history of previous VTE at low risk of recurrences, but this approach should be tested in larger trials in highly selected patients.
Mots-clé
Aged, Anticoagulants/administration & dosage, Anticoagulants/therapeutic use, Cohort Studies, Drug Monitoring, Early Termination of Clinical Trials, Female, Fibrin Fibrinogen Degradation Products/analysis, Follow-Up Studies, Humans, Incidence, Italy/epidemiology, Male, Middle Aged, Pilot Projects, Pulmonary Embolism/epidemiology, Pulmonary Embolism/etiology, Recurrence/prevention & control, Risk Factors, Venous Thromboembolism/blood, Venous Thromboembolism/drug therapy, Venous Thrombosis/epidemiology, Venous Thrombosis/etiology, Vitamin K/antagonists & inhibitors
Pubmed
Web of science
Open Access
Oui
Création de la notice
14/02/2013 13:36
Dernière modification de la notice
03/06/2020 6:26
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