Novel surface targets and serum biomarkers from the ovarian cancer vasculature.

Détails

ID Serval
serval:BIB_DDDBA7D1AA30
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Novel surface targets and serum biomarkers from the ovarian cancer vasculature.
Périodique
Cancer Biology and Therapy
Auteur⸱e⸱s
Sasaroli D., Gimotty P.A., Pathak H.B., Hammond R., Kougioumtzidou E., Katsaros D., Buckanovich R., Devarajan K., Sandaltzopoulos R., Godwin A.K., Scholler N., Coukos G.
ISSN
1555-8576 (Electronic)
ISSN-L
1538-4047
Statut éditorial
Publié
Date de publication
2011
Volume
12
Numéro
3
Pages
169-180
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.Publication Status: ppublish
Résumé
The molecular phenotype of tumor vasculature is different from normal vasculature, offering new opportunities for diagnosis and therapy of cancer, but the identification of tumor-restricted targets remains a challenge. We investigated 13 tumor vascular markers (TVMs) from 50 candidates identified through expression profiling of ovarian cancer vascular cells and selected to be either transmembrane or secreted, and to be either absent or expressed at low levels in normal tissues while overexpressed in tumors, based on analysis of 1,110 normal and tumor tissues from publicly available Affymetrix microarray data. Tumor-specific expression of each TVM was confirmed at the protein level in tumor tissue and/or in serum. Among the 13 TVMs, 11 were expressed on tumor vascular endothelium; the remaining 2 TVMs were expressed by tumor leukocytes. Our results demonstrate that certain transmembrane TVMs such as ADAM12 and CDCP1 are selectively expressed in tumor vasculature and represent promising targets for vascular imaging or anti-vascular therapy of epithelial ovarian cancer, while secreted or shed molecules such as TNFRSF21/DR6 can function as serum biomarkers. We have identified novel tumor-specific vasculature markers which appear promising for cancer serum diagnostics, molecular imaging and/or therapeutic targeting applications and warrant further clinical development.
Mots-clé
ADAM Proteins/genetics, ADAM Proteins/metabolism, Antigens, CD/genetics, Antigens, CD/metabolism, Cell Adhesion Molecules/genetics, Cell Adhesion Molecules/metabolism, Cell Hypoxia/genetics, Female, Gene Expression Regulation, Neoplastic, Humans, Membrane Proteins/genetics, Membrane Proteins/metabolism, Neoplasm Proteins/genetics, Neoplasm Proteins/metabolism, Neoplasms, Glandular and Epithelial/blood supply, Neoplasms, Glandular and Epithelial/metabolism, Ovarian Neoplasms/blood supply, Ovarian Neoplasms/metabolism, Receptors, Tumor Necrosis Factor/blood, Reference Values, Reverse Transcriptase Polymerase Chain Reaction, Tumor Markers, Biological/blood, Tumor Markers, Biological/genetics
Pubmed
Web of science
Création de la notice
14/10/2014 12:43
Dernière modification de la notice
20/08/2019 17:02
Données d'usage