Systems Genetics of Metabolism: The Use of the BXD Murine Reference Panel for Multiscalar Integration of Traits.

Détails

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_DD92637F1527
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Systems Genetics of Metabolism: The Use of the BXD Murine Reference Panel for Multiscalar Integration of Traits.
Périodique
Cell
Auteur(s)
Andreux P.A., Williams E.G., Koutnikova H., Houtkooper R.H., Champy M.F., Henry H., Schoonjans K., Williams R.W., Auwerx J.
ISSN
1097-4172 (Electronic)
ISSN-L
0092-8674
Statut éditorial
Publié
Date de publication
2012
Volume
150
Numéro
6
Pages
1287-1299
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Metabolic homeostasis is achieved by complex molecular and cellular networks that differ significantly among individuals and are difficult to model with genetically engineered lines of mice optimized to study single gene function. Here, we systematically acquired metabolic phenotypes by using the EUMODIC EMPReSS protocols across a large panel of isogenic but diverse strains of mice (BXD type) to study the genetic control of metabolism. We generated and analyzed 140 classical phenotypes and deposited these in an open-access web service for systems genetics (www.genenetwork.org). Heritability, influence of sex, and genetic modifiers of traits were examined singly and jointly by using quantitative-trait locus (QTL) and expression QTL-mapping methods. Traits and networks were linked to loci encompassing both known variants and novel candidate genes, including alkaline phosphatase (ALPL), here linked to hypophosphatasia. The assembled and curated phenotypes provide key resources and exemplars that can be used to dissect complex metabolic traits and disorders.
Pubmed
Web of science
Open Access
Oui
Création de la notice
26/10/2012 19:16
Dernière modification de la notice
20/08/2019 17:02
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