Functional genomics of intracellular bacteria.

Détails

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Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_DD8D1D81ED93
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Functional genomics of intracellular bacteria.
Périodique
Briefings In Functional Genomics
Auteur⸱e⸱s
de Barsy M., Greub G.
ISSN
2041-2657 (Electronic)
ISSN-L
2041-2649
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
12
Numéro
4
Pages
341-353
Langue
anglais
Résumé
During the genomic era, a large amount of whole-genome sequences accumulated, which identified many hypothetical proteins of unknown function. Rapidly, functional genomics, which is the research domain that assign a function to a given gene product, has thus been developed. Functional genomics of intracellular pathogenic bacteria exhibit specific peculiarities due to the fastidious growth of most of these intracellular micro-organisms, due to the close interaction with the host cell, due to the risk of contamination of experiments with host cell proteins and, for some strict intracellular bacteria such as Chlamydia, due to the absence of simple genetic system to manipulate the bacterial genome. To identify virulence factors of intracellular pathogenic bacteria, functional genomics often rely on bioinformatic analyses compared with model organisms such as Escherichia coli and Bacillus subtilis. The use of heterologous expression is another common approach. Given the intracellular lifestyle and the many effectors that are used by the intracellular bacteria to corrupt host cell functions, functional genomics is also often targeting the identification of new effectors such as those of the T4SS of Brucella and Legionella.
Pubmed
Web of science
Open Access
Oui
Création de la notice
20/09/2013 17:34
Dernière modification de la notice
20/08/2019 16:02
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