Treatment options in the management of status epilepticus.

Détails

Ressource 1Télécharger: serval:BIB_DD8B53517150.P001 (503.47 [Ko])
Etat: Public
Version: de l'auteur
Licence: Non spécifiée
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ID Serval
serval:BIB_DD8B53517150
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Treatment options in the management of status epilepticus.
Périodique
Current treatment options in neurology
Auteur(s)
Rossetti A.O.
ISSN
1534-3138 (Electronic)
ISSN-L
1092-8480
Statut éditorial
Publié
Date de publication
03/2010
Peer-reviewed
Oui
Volume
12
Numéro
2
Pages
100-112
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Status epilepticus treatment involves the use of several pharmacologic compounds, which are conceptually divided into three successive and additional lines of action. Because of their rapid onset of action, benzodiazepines represent the first approach; these are followed by classic antiepileptic drugs that are administered intravenously. In refractory episodes, pharmacologic coma induction with an appropriate anesthetic is advocated. Apart from first-line compounds, the level of evidence for medications used in status epilepticus is extremely limited. It is important to specifically address etiology in order to maximize the impact of the antiepileptic therapy. Fine-tuning of the treatment strategy, mainly regarding the choice of whether to induce coma, should be approached by balancing the benefits of rapid control of the status epilepticus with the risks of adverse effects. Although each status epilepticus episode should be treated as rapidly as possible, it appears advisable to reserve coma induction for those forms, such as generalized convulsive status, that have been shown to present a consistent risk of neurologic sequelae.

Mots-clé
Refractory Status Epilepticus, Nonconvulsive Status Epilepticus, Acute Repetitive Seizures, Intravenous Valproate, Pharmacokinetics, Propofol, Levetiracetam, Phenytoin, Midazolam, Infusion, Clinical Neurology
Pubmed
Web of science
Open Access
Oui
Création de la notice
18/05/2010 15:26
Dernière modification de la notice
01/10/2019 6:19
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