Humoral response to defined Plasmodium falciparum antigens in cerebral and uncomplicated malaria and their relationship to parasite genotype

Détails

ID Serval
serval:BIB_DD711CE82207
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Humoral response to defined Plasmodium falciparum antigens in cerebral and uncomplicated malaria and their relationship to parasite genotype
Périodique
American Journal of Tropical Medicine and Hygiène
Auteur⸱e⸱s
Al-Yaman  F., Genton  B., Reeder  J. C., Mokela  D., Anders  R. F., Alpers  M. P.
ISSN
0002-9637 (Print)
Statut éditorial
Publié
Date de publication
04/1997
Volume
56
Numéro
4
Pages
430-5
Notes
Journal Article --- Old month value: Apr
Résumé
The prevalence and concentration of IgG antibodies to defined Plasmodium falciparum antigens were assessed in serum samples of 97 children with cerebral malaria and 146 children with uncomplicated malaria. The antigens used included the schizont extract, ring-infected erythrocyte surface antigen, the C-terminal region of merozoite surface antigen-1 (MSA-1) (BVp42), and three recombinant proteins of MSA-2 (FC27, 3D7, and d3D7). Parasite isolates from 24 children with cerebral malaria and 22 children with uncomplicated malaria were genotyped for MSA-1 and MSA-2. The distribution of parasite genotypes belonging to the different allelic families was similar in both the cerebral and uncomplicated malaria groups. There were higher antibody levels to antigens derived from the infecting parasite genotype than to heterologous genotypes, but this difference was only statistically significant for antibody against the d3D7 antigen among children infected with the 3D7 parasite genotype (mean log = 4.72 versus 3.45 antibody units [AU]; P = 0.029). Those who died were more likely to be infected with the FC27 genotype and had lower antibody levels to MSA-2 of the 3D7 type than had cerebral malaria patients who survived (mean log = 2.94 versus 3.79 AU; P = 0.049). Antibodies against parasites of the 3D7 genotype are associated with a better prognosis among children with cerebral malaria partly because these children are more likely to be infected with parasites of this genotype rather than the FC27 genotype, which appears to be more virulent.
Mots-clé
Acute Disease Adolescent Animals Antibodies, Protozoan/*biosynthesis Antigens, Protozoan/*immunology Antigens, Surface/genetics/immunology Child Child, Preschool Female Genotype Hemoglobins/analysis Humans Immunoglobulin G/biosynthesis Infant Leukocyte Count Malaria, Cerebral/*immunology/parasitology Malaria, Falciparum/*immunology/parasitology Male Merozoite Surface Protein 1 Plasmodium falciparum/genetics/*immunology Protein Precursors/genetics/immunology Protozoan Proteins/genetics/immunology
Pubmed
Web of science
Création de la notice
28/01/2008 12:49
Dernière modification de la notice
20/08/2019 17:02
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