Agents anti-infectieux et fonction réna!e: vers des posologies sur mesure [Antimicrobial agents and renal elimination: towards individual dosage adjustment?].

Détails

ID Serval
serval:BIB_DD6FE1F6DCBC
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Agents anti-infectieux et fonction réna!e: vers des posologies sur mesure [Antimicrobial agents and renal elimination: towards individual dosage adjustment?].
Périodique
Revue Médicale Suisse
Auteur(s)
Willi-Robatel C., Senn L., Livio F., Zanetti G., Marchetti O., Buclin T.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Statut éditorial
Publié
Date de publication
2012
Volume
8
Numéro
338
Pages
894-900
Langue
français
Notes
Publication types: English Abstract ; Journal Article ; Review
Résumé
The efficacy and safety of anti-infective treatments are associated with the drug blood concentration profile, which is directly correlated with a dosing adjustment to the individual patient's condition. Dosing adjustments to the renal function recommended in reference books are often imprecise and infrequently applied in clinical practice. The recent generalisation of the KDOQI (Kidney Disease Outcome Quality Initiative) staging of chronically impaired renal function represents an opportunity to review and refine the dosing recommendations in patients with renal insufficiency. The literature has been reviewed and compared to a predictive model of the fraction of drug cleared by the kidney based on the Dettli's principle. Revised drug dosing recommendations integrating these predictive parameters are proposed.
Mots-clé
Anti-Infective Agents/administration & dosage, Anti-Infective Agents/pharmacokinetics, Dose-Response Relationship, Drug, Drug Dosage Calculations, Humans, Individualized Medicine/methods, Individualized Medicine/trends, Kidney/metabolism, Metabolic Clearance Rate/physiology, Metabolic Detoxication, Drug/physiology, Practice Guidelines as Topic
Pubmed
Création de la notice
18/01/2012 15:29
Dernière modification de la notice
20/10/2020 11:12
Données d'usage