Metabolic communication in tumors: a new layer of immunoregulation for immune evasion.

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_DD5E2FA95B5C
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Metabolic communication in tumors: a new layer of immunoregulation for immune evasion.
Périodique
Journal For Immunotherapy of Cancer
Auteur(s)
Ho P.C., Liu P.S.
ISSN
2051-1426 (Electronic)
ISSN-L
2051-1426
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
4
Pages
4
Langue
anglais
Résumé
The success of cancer immunotherapy reveals the power of host immunity on killing cancer cells and the feasibility to unleash restraints of anti-tumor immunity. However, the immunosuppressive tumor microenvironment and low immunogenicity of cancer cells restrict the therapeutic efficacy of cancer immunotherapies in a small fraction of patients. Therefore deciphering the underlying mechanisms promoting the generation of an immunosuppressive tumor microenvironment is direly needed to better harness host anti-tumor immunity. Early works revealed that deregulated metabolic activities in cancer cells support unrestricted proliferation and survival by producing macromolecules. Intriguingly, recent studies uncovered that metabolic switch in immune and endothelial cells modulate cellular activities and contribute to the progression of several diseases, including cancers. Herein, we review the progress on immunometabolic regulations on fine-tuning activities of immune cells and discuss how metabolic communication between cancer and infiltrating immune cells contributes to cancer immune evasion. Moreover, we would like to discuss how we might exploit this knowledge to improve current immunotherapies and the unresolved issues in this field.
Pubmed
Open Access
Oui
Création de la notice
20/02/2016 17:23
Dernière modification de la notice
20/08/2019 17:02
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