Hemodynamic, metabolic and hormonal responses to oral glibenclamide in patients with cirrhosis receiving glucose.

Détails

ID Serval
serval:BIB_DD45002A69F7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Hemodynamic, metabolic and hormonal responses to oral glibenclamide in patients with cirrhosis receiving glucose.
Périodique
Scandinavian Journal of Gastroenterology
Auteur⸱e⸱s
Moreau R., Chagneau C., Heller J., Chevenne D., Langlet P., Deltenre P., Hillaire S., Lefilliatre P., Pateron D., Sogni P., Valla D., Lebrec D.
ISSN
0036-5521 (Print)
ISSN-L
0036-5521
Statut éditorial
Publié
Date de publication
2001
Volume
36
Numéro
3
Pages
303-308
Langue
anglais
Notes
Publication types: Clinical Trial ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
BACKGROUND: In patients with cirrhosis, glucose may induce splanchnic and renal vasodilation. Since the antidiabetic sulfonylurea glibenclamide is known to induce splanchnic and renal vasoconstriction in portal hypertensive animals, this drug may inhibit glucose-induced hemodynamic responses in patients with cirrhosis. The aim of the present study was to investigate, in patients with cirrhosis, the short-term effects of glibenclamide on hemodynamic and humoral responses to glucose.
METHODS: Patients were randomly assigned to receive either glibenclamide (5-mg tablet) or a placebo. All patients received an infusion of 10% glucose (62.5 ml/h for 12 h) that was started at the same time as glibenclamide or placebo administration. Studies were performed prior to and 90 min after glibenclamide or placebo.
RESULTS: Glibenclamide (i.e. glibenclamide plus glucose) significantly increased plasma insulin concentrations and glycemia while placebo (i.e. glucose alone) significantly increased glycemia but did not change plasma insulin levels. Glibenclamide did not significantly change the hepatic venous pressure gradient while this value was significantly increased following glucose alone. Glibenclamide did not significantly change renal blood flow and glomerular filtration rate while glucose alone significantly increased renal blood flow without affecting the glomerular filtration rate. Glibenclamide significantly decreased cardiac index while glucose alone did not change this value.
CONCLUSIONS: In patients with cirrhosis receiving glucose, glibenclamide blunted glucose-induced splanchnic and renal vasodilation. In addition, glibenclamide per se induced a decrease in cardiac index. These findings should be taken into account when glibenclamide is administered to patients with cirrhosis and type 2 diabetes.
Mots-clé
Administration, Oral, Female, Glucose/administration & dosage, Glyburide/administration & dosage, Hemodynamics/drug effects, Humans, Hypoglycemic Agents/administration & dosage, Infusions, Intravenous, Insulin/metabolism, Liver/drug effects, Liver/metabolism, Liver Cirrhosis/physiopathology, Liver Function Tests, Male, Middle Aged, Probability, Reference Values, Respiratory Function Tests, Treatment Outcome
Pubmed
Web of science
Création de la notice
06/12/2013 10:29
Dernière modification de la notice
20/08/2019 16:02
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