Importance of L3T4+ and Lyt-2+ cells in the immunologic control of infection with Mycobacterium bovis strain bacillus Calmette-Guerin in mice. Assessment by elimination of T cell subsets in vivo

Détails

ID Serval
serval:BIB_DD413F24DB4D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Importance of L3T4+ and Lyt-2+ cells in the immunologic control of infection with Mycobacterium bovis strain bacillus Calmette-Guerin in mice. Assessment by elimination of T cell subsets in vivo
Périodique
Journal of Immunology
Auteur(s)
Pedrazzini  T., Hug  K., Louis  J. A.
ISSN
0022-1767 (Print)
Statut éditorial
Publié
Date de publication
09/1987
Volume
139
Numéro
6
Pages
2032-7
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Sep 15
Résumé
The course of infection after injection of small doses of bacillus Calmette-Guerin (BCG) was studied in mice which were depleted in vivo of T cell subsets by administration of either anti-L3T4 or anti-Lyt-2 mAb. The results presented herein strongly suggest that the L3T4+ subpopulation play a pivotal role in the immunologic control of BCG infection because the depletion of L3T4+ cells led to a dramatic increase in the number of viable bacteria. Depletion of Lyt-2+ cells had no significant effect on the course of infection. These results were confirmed by using adoptive transfer experiments which showed that protective immunity was mediated by L3T4+ cells generated in the spleen as a result of infection. Moreover, T cells capable of controlling the recurrence of BCG multiplication from residual bacteria remaining in organs after the recovery from infection were shown to belong to the L3T4+ subpopulation.
Mots-clé
Animals Antibodies, Monoclonal/diagnostic use Antigens, Differentiation, T-Lymphocyte Antigens, Ly/*immunology Antigens, Surface/*immunology Immunization, Passive Mice Mycobacterium bovis/*immunology Spleen/immunology T-Lymphocytes/classification/*immunology Time Factors Tuberculosis/*veterinary
Pubmed
Web of science
Création de la notice
25/01/2008 8:45
Dernière modification de la notice
20/08/2019 16:02
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