Statistically significant changes of antimüllerian hormone and inhibin levels during the physiologic menstrual cycle in reproductive age women.

Détails

ID Serval
serval:BIB_DCCAA13813FE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Statistically significant changes of antimüllerian hormone and inhibin levels during the physiologic menstrual cycle in reproductive age women.
Périodique
Fertility and Sterility
Auteur(s)
Wunder D.M., Bersinger N.A., Yared M., Kretschmer R., Birkhäuser M.H.
ISSN
1556-5653[electronic]
Statut éditorial
Publié
Date de publication
2008
Volume
89
Numéro
4
Pages
927-933
Langue
anglais
Résumé
OBJECTIVE: To define the dynamics of antimüllerian hormone (AMH) and inhibins during the physiologic menstrual cycle. DESIGN: Longitudinal study. SETTING: University hospital. PATIENT(S): 36 young, healthy, normal weight Caucasian women without medication. INTERVENTION(S): Normal ovulatory menstrual cycles were evaluated by regular blood sampling taken every other day and periovulatory every day. MAIN OUTCOME MEASURE(S): Serum concentrations of AMH, inhibin A and B, follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, estradiol, progesterone, and free testosterone were measured in all blood samples. RESULT(S): Median AMH levels are statistically significantly higher in the late follicular compared with ovulation or the early luteal phase. There are statistically significant correlations between both AMH and FSH, and AMH and free testosterone in all cycle phases. Inhibin A increases strongly in the late follicular phase and peaks at day LH + 4. Inhibin B shows a broad midfollicular and a sharp early luteal peak, the difference being statistically significant between day LH + 4 and the earlier time points and between day LH + 2 and day LH. Although there is a negative association between inhibin A or B and the body mass index (BMI), there is no correlation between AMH and the BMI. CONCLUSION(S): Levels of AMH show a statistically significant change during the menstrual cycle and may influence the circulating gonadotropin and steroid hormone levels.
Mots-clé
Adult, Anti-Mullerian Hormone, Body Mass Index, Estradiol, Female, Follicle Stimulating Hormone, Humans, Inhibins, Longitudinal Studies, Luteinizing Hormone, Menstrual Cycle, Progesterone, Prolactin, Reference Values, Reproduction, Testosterone, Time Factors
Pubmed
Web of science
Création de la notice
04/03/2009 19:13
Dernière modification de la notice
20/08/2019 16:01
Données d'usage