The left medial temporal region and schizophrenia. A PET study.

Détails

ID Serval
serval:BIB_DCB38897FDE8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The left medial temporal region and schizophrenia. A PET study.
Périodique
Brain
Auteur(s)
Friston K.J., Liddle P.F., Frith C.D., Hirsch S.R., Frackowiak R.S.
ISSN
0006-8950 (Print)
ISSN-L
0006-8950
Statut éditorial
Publié
Date de publication
1992
Volume
115 ( Pt 2)
Pages
367-382
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
Regional cerebral blood flow (rCBF) was measured in 30 schizophrenic patients with severe, persistent and stable symptoms using positron emission tomography (PET). Directed and non-directed correlational analysis of the relationship between psychopathology and rCBF was used to identify brain structures implicated in three behavioural subsyndromes of schizophrenia. Psychopathology and neurophysiology (rCBF) exhibited high correlations in the left medial temporal region, mesencephalic, thalamic and left striatal structures. The highest correlation was in the left parahippocampal region. A canonical analysis of the same data highlighted the left parahippocampal region and left striatum (globus pallidus) as sites which linked the behavioural subsyndromes in terms of shared rCBF correlates. Increasing severity of psychopathology was associated with increased rCBF in these regions. Disinhibition of left medial temporal lobe activity mediated by fronto-limbic connections is a possible explanation for these findings; however, the prefrontal component appears to be critically dependent on the behavioural subsyndrome.
Mots-clé
Adult, Cerebrovascular Circulation, Factor Analysis, Statistical, Female, Humans, Male, Middle Aged, Schizophrenia/physiopathology, Schizophrenia/radionuclide imaging, Temporal Lobe/radionuclide imaging, Tomography, Emission-Computed
Pubmed
Web of science
Création de la notice
25/09/2011 16:19
Dernière modification de la notice
20/08/2019 16:01
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