Infection of B cells with hepatitis C virus for the development of lymphoproliferative disorders in patients with chronic hepatitis C.

Détails

ID Serval
serval:BIB_DCB2214822F3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Infection of B cells with hepatitis C virus for the development of lymphoproliferative disorders in patients with chronic hepatitis C.
Périodique
Journal of Medical Virology
Auteur(s)
Inokuchi M., Ito T., Uchikoshi M., Shimozuma Y., Morikawa K., Nozawa H., Shimazaki T., Hiroishi K., Miyakawa Y., Imawari M.
ISSN
1096-9071[electronic]
Statut éditorial
Publié
Date de publication
2009
Volume
81
Numéro
4
Pages
619-627
Langue
anglais
Résumé
Infection with hepatitis C virus (HCV) is associated with lymphoproliferative disorders, represented by essential mixed cryoglobulinemia and B-cell non-Hodgkin's lymphoma, but the pathogenic mechanism remains obscure. HCV may infect B cells or interact with their cell surface receptors, and induce lymphoproliferation. The influence of HCV infection of B cells on the development of lymphoproliferative disorders was evaluated in 75 patients with persistent HCV infection. HCV infection was more prevalent (63% vs. 16%, 14%, or 17% P < 0.05 for each), and HCV RNA levels were higher (3.35 +/- 3.85 vs. 1.75 +/- 2.52, 2.15 +/- 2.94 or 2.10 +/- 2.90 log copies/100 ng, P < 0.01 for each) in B cells than CD4(+), CD8(+) T cells or other cells. Negative-strand HCV RNA, as a marker of viral replication, was detected in B cells from four of the 75 (5%) patients. Markers for lymphoproliferative disorders were more frequent in the 50 patients with chronic hepatitis C than the 32 with chronic hepatitis B, including cryoglobulinemia (26% vs. 0%, P < 0.001), low CH(50) levels (48% vs. 3%, P = 0.012), and the clonality of B cells (12% vs. 0%, P < 0.01). By multivariate analysis, HCV RNA in B cells was an independent factor associated with the presence of at least one marker for lymphoproliferation (odds ratio: 1.98 [95% confidence interval: 1.36-7.24], P = 0.027). Based on the results obtained, the infection of B cells with HCV would play an important role in the development of lymphoproliferative disorders.
Mots-clé
Adult, Aged, Amino Acid Sequence, B-Lymphocytes/pathology, B-Lymphocytes/virology, Female, Genes, Immunoglobulin Heavy Chain/genetics, Hepacivirus/pathogenicity, Hepacivirus/physiology, Hepatitis C, Chronic/complications, Hepatitis C, Chronic/epidemiology, Humans, Lymphoproliferative Disorders/epidemiology, Lymphoproliferative Disorders/pathology, Male, Middle Aged, Molecular Sequence Data, Prevalence, RNA, Viral/blood, Virus Replication
Pubmed
Web of science
Création de la notice
21/01/2010 17:33
Dernière modification de la notice
20/08/2019 16:01
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