Direct physical interaction between the Caenorhabditis elegans 'death proteins' CED-3 and CED-4

Détails

ID Serval
serval:BIB_DC78F5A8A0E9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Direct physical interaction between the Caenorhabditis elegans 'death proteins' CED-3 and CED-4
Périodique
FEBS Letters
Auteur(s)
Irmler  M., Hofmann  K., Vaux  D., Tschopp  J.
ISSN
0014-5793 (Print)
Statut éditorial
Publié
Date de publication
04/1997
Volume
406
Numéro
1-2
Pages
189-90
Notes
Journal Article --- Old month value: Apr 7
Résumé
The two genes CED-4 and CED-3 (the nematode homologue of interleukin-1beta converting enzyme, ICE) of Caenorhabditis elegans are implicated in the control of cell death, but the mechanism by which this occurs is unknown. Here we provide evidence that CED-3 and CED-4 both contain sequences with homology to a domain present in RAIDD and the prodomain of certain ICE-like proteases (caspases). This domain is known to establish an interaction between RAIDD and these caspases. Similarly, CED-4 was found to interact with CED-3. Thus, the activity of the death protease CED-3 appears to be controlled by CED-4 through a direct physical interaction.
Mots-clé
Amino Acid Sequence Animals Caenorhabditis elegans/*chemistry *Caenorhabditis elegans Proteins Calcium-Binding Proteins/*chemistry *Caspases Helminth Proteins/*chemistry Humans Molecular Sequence Data Sequence Homology, Amino Acid
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 15:18
Dernière modification de la notice
20/08/2019 16:01
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