Long term retention of retigabine in a cohort of people with drug resistant epilepsy.

Détails

ID Serval
serval:BIB_DC614613FA05
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Long term retention of retigabine in a cohort of people with drug resistant epilepsy.
Périodique
Seizure
Auteur⸱e⸱s
Wehner T., Chinnasami S., Novy J., Bell G.S., Duncan J.S., Sander J.W.
ISSN
1532-2688 (Electronic)
ISSN-L
1059-1311
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
23
Numéro
10
Pages
878-881
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
PURPOSE: To assess the utility of retigabine (RTG) for epilepsy in clinical practice at a single UK tertiary centre.
METHODS: We identified all individuals who were offered RTG from April 2011 to May 2013. We collected demographics, seizure types, previous and current antiepileptic drugs (AEDs), starting and maximum attained daily dose of RTG, clinical benefits, side effects, and reason to discontinue RTG from in- and outpatient encounters until February 28, 2014.
RESULTS: 145 people who had failed a median of 11 AEDs took at least one dose of RTG. One year retention was 32% and decreased following the safety alert by the US Federal Drug Administration (FDA) in April 2013. None became seizure free. 34 people (24%) reported a benefit that was ongoing at last assessment in five (3%). The most relevant benefit was the significant reduction or cessation of drop attacks or seizure-related falls in four women, this persisted at last assessment in two. The presence of simple partial seizures was associated with longer retention, as was a higher attained dose of RTG. Adverse effects were seen in 74% and largely CNS-related or nonspecific and affected the genitourinary system in 13%.
CONCLUSION: Retention of RTG was less favourable compared to data from open label extension studies of the regulatory trials. In comparison with historical data on similar retention audits retention of RTG at one year appears to be less than lamotrigine, topiramate, levetiracetam, pregabalin, zonisamide, and lacosamide, and slightly higher than gabapentin.
Pubmed
Web of science
Open Access
Oui
Création de la notice
02/01/2015 10:36
Dernière modification de la notice
20/08/2019 17:01
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