Atrial natriuretic peptide and urinary prostaglandins in man.

Détails

ID Serval
serval:BIB_DC3CC6D5879F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Atrial natriuretic peptide and urinary prostaglandins in man.
Périodique
British Journal of Clinical Pharmacology
Auteur(s)
Benzoni D., Geoffroy J., Waeber B., Brunner H.R., Biollaz J., Sassard J.
ISSN
0306-5251 (Print)
ISSN-L
0306-5251
Statut éditorial
Publié
Date de publication
1989
Volume
28
Numéro
4
Pages
397-402
Langue
anglais
Notes
Publication types: Clinical Trial ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
1. In order to assess the effects of atrial natriuretic factor on the renal biosynthesis of prostaglandins (PG), the urinary excretion of PGE2, PGF2 alpha, 6-keto-PGF1 alpha and thromboxane (Tx)B2 were followed in eight salt-loaded healthy volunteers infused for 2 h with a non hypotensive dose of human atrial natriuretic peptide (hANP, 0.7 nmol min-1). 2. Within 1 h, hANP, infusion produced a marked increase in the urinary PG output, especially of PGE2 and 6-keto-PGF1 alpha (188 +/- 21% and 202 +/- 24% of the pre-infusion values respectively), followed by a significant decrease during the recovery period. 3. No correlations could be uncovered between the urinary excretion of sodium and that of any of the PGs. In contrast, during the infusion of hANP, the urinary output of PGE2 and of 6-keto-PGF1 alpha was found positively related to the urinary flow rate (r = 0.42; P less than 0.05; n = 32 and r = 0.43; P less than 0.05; n = 32 respectively) as well as during the recovery period (r = 0.66, P less than 0.001; n = 32 and r = 0.55; P less than 0.01; n = 32 respectively). 4. It was concluded that, in man, infusion of a non hypotensive dose of hANP is followed by a rise in urinary PG excretion presumably reflecting enhanced renal PG biosynthesis. This increased urinary PG excretion does not seem to be involved in the natriuretic action of hANP but might participate to its diuretic effect.
Mots-clé
Adult, Atrial Natriuretic Factor/physiology, Glomerular Filtration Rate, Hemodynamics/drug effects, Humans, Male, Prostaglandins/urine, Renal Circulation
Pubmed
Web of science
Création de la notice
25/01/2008 10:41
Dernière modification de la notice
20/08/2019 16:01
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