CXCL5 drives obesity to diabetes, and further.

Détails

ID Serval
serval:BIB_DC2254A43F64
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
CXCL5 drives obesity to diabetes, and further.
Périodique
Aging
Auteur(s)
Chavey C., Fajas L.
ISSN
1945-4589 (Electronic)
ISSN-L
1945-4589
Statut éditorial
Publié
Date de publication
2009
Volume
1
Numéro
7
Pages
674-677
Langue
anglais
Résumé
We have recently shown that the CXCL5 chemokine is secreted by adipose tissue in the obese state. We demonstrated that adipose tissue-derived CXCL5 mediates insulin resistance in muscle. We speculate in this paper that CXCL5 could also mediate other obesity, and diabetes-derived pathologies, such as cardiovascular disease, retinopathy, or inflammatory bowel disease. In this scenario CXCL5 targeted therapy would prevent not only the development of type II diabetes in obese subjects, but also several other obesity-related co morbidities. Finally we propose to analyze the CXCL5 gene to find particular polymorphisms that could predict the development of type II diabetes in obese subjects.
Mots-clé
Animals, Chemokine CXCL5/genetics, Chemokine CXCL5/metabolism, Diabetes Complications/etiology, Diabetes Complications/metabolism, Diabetes Mellitus, Type 2/etiology, Diabetes Mellitus, Type 2/genetics, Humans, Insulin Resistance/physiology, Obesity/complications, Obesity/metabolism, Polymorphism, Genetic/genetics, Receptors, Interleukin-8B/metabolism
Pubmed
Web of science
Création de la notice
07/03/2013 15:56
Dernière modification de la notice
20/08/2019 16:01
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