Experimentally induced cutaneous leishmaniasis: are L3T4+ T cells that promote parasite growth distinct from those mediating resistance?

Détails

ID Serval
serval:BIB_DBC7ECE895A4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Experimentally induced cutaneous leishmaniasis: are L3T4+ T cells that promote parasite growth distinct from those mediating resistance?
Périodique
Immunology Letters
Auteur(s)
Muller  I., Pedrazzini  T., Louis  J. A.
ISSN
0165-2478 (Print)
Statut éditorial
Publié
Date de publication
11/1988
Volume
19
Numéro
3
Pages
251-9
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Nov
Résumé
A considerable body of evidence from various laboratories indicates that specific T cell responses generated during infection with Leishmania parasites play an important role both in the resolution and progression of cutaneous leishmaniasis. Recent data, summarized in this article, indicate that resolution of lesions and promotion of disease not only result from the activity of functionally distinct parasite-specific L3T4+ T cells but could also be mediated by functionally similar L3T4+ T cells differing only in their fine antigenic specificity. This contention is based on observations which suggests that (a) the induction of T cell tolerance to parasite antigens present during the early phase of infection is beneficial to the host, and (b) the specificity of L3T4+ T cell lines and clones capable of exacerbating the development of lesions is different from that of T cells mediating protection.
Mots-clé
Animals Antibodies, Monoclonal Antigens, Protozoan/*immunology Immune Tolerance *Immunity, Cellular Immunosuppression Leishmania tropica/growth & development Leishmaniasis/*immunology/pathology Mice Mice, Inbred BALB C Skin/*pathology T-Lymphocytes/*immunology
Pubmed
Web of science
Création de la notice
25/01/2008 8:45
Dernière modification de la notice
20/08/2019 16:00
Données d'usage