The fragile X protein binds mRNAs involved in cancer progression and modulates metastasis formation

Détails

ID Serval
serval:BIB_DAD855B2E6A4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The fragile X protein binds mRNAs involved in cancer progression and modulates metastasis formation
Périodique
EMBO molecular medicine
Auteur(s)
Luca R., Averna M., Zalfa F., Vecchi M., Bianchi F., La Fata G., Del Nonno F., Nardacci R., Bianchi M., Nuciforo P., Munck S., Parrella P., Moura R., Signori E., Alston R., Kuchnio A., Farace M. G., Fazio V. M., Piacentini M., De Strooper B., Achsel T., Neri G., Neven P., Evans D. G., Carmeliet P., Mazzone M., Bagni C.
ISSN
1757-4684 (Electronic)
ISSN-L
1757-4676
Statut éditorial
Publié
Date de publication
10/2013
Peer-reviewed
Oui
Volume
5
Numéro
10
Pages
1523-36
Langue
anglais
Notes
Luca, Rossella
Averna, Michele
Zalfa, Francesca
Vecchi, Manuela
Bianchi, Fabrizio
La Fata, Giorgio
Del Nonno, Franca
Nardacci, Roberta
Bianchi, Marco
Nuciforo, Paolo
Munck, Sebastian
Parrella, Paola
Moura, Rute
Signori, Emanuela
Alston, Robert
Kuchnio, Anna
Farace, Maria Giulia
Fazio, Vito Michele
Piacentini, Mauro
De Strooper, Bart
Achsel, Tilmann
Neri, Giovanni
Neven, Patrick
Evans, D Gareth
Carmeliet, Peter
Mazzone, Massimiliano
Bagni, Claudia
eng
Research Support, Non-U.S. Gov't
England
2013/10/05 06:00
EMBO Mol Med. 2013 Oct;5(10):1523-36. doi: 10.1002/emmm.201302847. Epub 2013 Sep 16.
Résumé
The role of the fragile X mental retardation protein (FMRP) is well established in brain, where its absence leads to the fragile X syndrome (FXS). FMRP is almost ubiquitously expressed, suggesting that, in addition to its effects in brain, it may have fundamental roles in other organs. There is evidence that FMRP expression can be linked to cancer. FMR1 mRNA, encoding FMRP, is overexpressed in hepatocellular carcinoma cells. A decreased risk of cancer has been reported in patients with FXS while a patient-case with FXS showed an unusual decrease of tumour brain invasiveness. However, a role for FMRP in regulating cancer biology, if any, remains unknown. We show here that FMRP and FMR1 mRNA levels correlate with prognostic indicators of aggressive breast cancer, lung metastases probability and triple negative breast cancer (TNBC). We establish that FMRP overexpression in murine breast primary tumours enhances lung metastasis while its reduction has the opposite effect regulating cell spreading and invasion. FMRP binds mRNAs involved in epithelial mesenchymal transition (EMT) and invasion including E-cadherin and Vimentin mRNAs, hallmarks of EMT and cancer progression.
Mots-clé
Animals, Breast Neoplasms/metabolism/pathology, Cadherins/metabolism, Cell Adhesion, Cell Line, Tumor, Cell Movement, Cell Shape, Disease Progression, Epithelial-Mesenchymal Transition, Female, Fragile X Mental Retardation Protein/antagonists &, inhibitors/genetics/*metabolism, Humans, Immunohistochemistry, Lung Neoplasms/metabolism/pathology/secondary, Mice, RNA Interference, RNA, Messenger/*metabolism, RNA, Small Interfering/metabolism, Vimentin/metabolism, Emt, Fmrp, Tnbc, cell invasion, mRNA metabolism
Pubmed
Open Access
Oui
Création de la notice
06/03/2017 18:23
Dernière modification de la notice
20/08/2019 16:59
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