Geoepidemiology of autoimmune hemolytic anemia.

Détails

ID Serval
serval:BIB_DAB819C3591C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Geoepidemiology of autoimmune hemolytic anemia.
Périodique
Autoimmunity Reviews
Auteur⸱e⸱s
Lambert Jean-Francois, Nydegger Urs E.
ISSN
1873-0183[electronic], 1568-9972[linking]
Statut éditorial
Publié
Date de publication
2010
Volume
9
Numéro
5
Pages
350-354
Langue
anglais
Résumé
Autoantibodies against red blood cell antigens are considered the diagnostic hallmark of AIHA: Direct antiglobulin test (DAT) completed by cytofluorometry and specific diagnostic monoclonal antibodies (mAbs) allow for a better understanding of autoimmune hemolytic anemia (AIHA) triggers. Once B-cell tolerance checkpoints are bypassed, the patient loses self-tolerance, if the AIHA is not also caused by an possible variety of secondary pathogenic events such as viral, neoplastic and underlying autoimmune entities, such as SLE or post-transplantation drawbacks; treatment of underlying diseases in secondary AIHA guides ways to curative AIHA treatment. The acute phase of AIHA, often lethal in former times, if readily diagnosed, must be treated using plasma exchange, extracorporeal immunoadsorption and/or RBC transfusion with donor RBCs devoid of the auto-antibody target antigen. Genotyping blood groups (www.bloodgen.com) and narrowing down the blood type subspecificities with diagnostic mAbs help to define the triggering autoantigen and to select well compatible donor RBC concentrates, which thus escape recognition by the autoantibodies.
Mots-clé
Autoimmune Hemolytic Anemia, Coombs Test, Antiglobulin Test, Direct Antiglobulin Test (DAT, Sometimes Referred to as 'Coombs Test', Immunoglobulin, Complement (C), Red-Cell Aplasia, Flow-Cytometry, Bound IGG, Autoantibodies, Transplantation, Vaccination, Children, Disease
Pubmed
Web of science
Création de la notice
27/04/2010 15:03
Dernière modification de la notice
20/08/2019 15:59
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