Genetique des neoplasies endocriniennes multiples: implications cliniques. [Genetics of multiple endocrine neoplasies: clinical implications]

Détails

ID Serval
serval:BIB_DA98D70B7E5E
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Genetique des neoplasies endocriniennes multiples: implications cliniques. [Genetics of multiple endocrine neoplasies: clinical implications]
Périodique
Revue Médicale Suisse
Auteur⸱e⸱s
Igaz  P., Gaillard  R. C.
ISSN
1660-9379 (Print)
Statut éditorial
Publié
Date de publication
02/2005
Volume
1
Numéro
6
Pages
408-13
Notes
English Abstract Journal Article Review --- Old month value: Feb 9
Résumé
The multiple endocrine neoplasia (MEN) syndromes are hereditary monogenic diseases that are transmitted as autosomal dominant traits, and are characterized by the development of tumors and hyperplasias in several endocrine organs. The causative genes of the 2 principal forms of MEN have been recently identified; a protooncogene for MEN2 (the RET gene) and a tumor suppressor gene for MEN1 (the MEN1 gene). Correlations between phenotype and genotype were described in the case of RET mutations that could help in defining the screening methods and the preferable age of prophylactic thyroidectomy. No correlations were established between the mutations of the MEN1 gene and the phenotype of patients suffering from MEN1. We present here a synopsis of the recent results of the genetics of MEN syndromes underlining their clinical implications.
Mots-clé
Humans Multiple Endocrine Neoplasia/*genetics Mutation Proto-Oncogene Proteins/genetics Receptor Protein-Tyrosine Kinases/genetics
Pubmed
Création de la notice
15/02/2008 16:57
Dernière modification de la notice
20/08/2019 15:59
Données d'usage