QuantiFERON-TB Gold assay for the diagnosis of latent tuberculosis infection.

Détails

ID Serval
serval:BIB_DA907107E191
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
QuantiFERON-TB Gold assay for the diagnosis of latent tuberculosis infection.
Périodique
Expert review of Molecular Diagnostics
Auteur⸱e⸱s
Manuel O., Kumar D.
ISSN
1744-8352
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
8
Numéro
3
Pages
247-256
Langue
anglais
Résumé
Tuberculin skin test (TST) has been used for 100 years for the diagnosis of latent tuberculosis (TB) infection (LTBI). In recent years, increasing interest in the diagnosis of TB has led to the development of new assays. QuantiFERON-TB Gold (QFT-G) is an IFN-gamma-release assay that measures the release of interferon after stimulation in vitro by Mycobacterium tuberculosis antigens. The main advantage of this assay with respect to TST is the lack of crossreaction with bacillus Calmette-Guérin and most nontuberculous mycobacteria. QFT-G also eliminates the need for the patient to return for test reading in 48-72 h. In the immunocompromised host and in pediatric populations, studies suggest that the QFT-G better correlates with the risk of TB than the TST, but data remain inconclusive. In contrast to TST, there are no prospective studies regarding the association of the QFT-G result and the risk for development of TB. Given its advantages, the QFT-G may become the standard test for the diagnosis of LTBI.
Mots-clé
Antigens, Bacterial, Humans, Interferon-gamma, Mycobacterium bovis, Mycobacterium tuberculosis, Reagent Kits, Diagnostic, Sensitivity and Specificity, Time Factors, Tuberculin Test, Tuberculosis
Pubmed
Web of science
Création de la notice
20/02/2009 11:20
Dernière modification de la notice
20/08/2019 15:59
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