Kinetics of RNA labeling in toad bladder epithelium: effects of aldosterone and related steroids
Détails
ID Serval
serval:BIB_DA8043787EB1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Kinetics of RNA labeling in toad bladder epithelium: effects of aldosterone and related steroids
Périodique
Proceedings of the National Academy of Sciences of the United States of America
ISSN
0027-8424
Statut éditorial
Publié
Date de publication
08/1974
Peer-reviewed
Oui
Volume
71
Numéro
8
Pages
3101-5
Notes
Journal Article --- Old month value: Aug
Résumé
Sucrose gradient analysis revealed an aldosterone-dependent increase in the incorporation of [(3)H]uridine into a nonmethylated, rapidly labeled RNA that sedimented at 9-12 S. This effect was antagonized by an anti-mineralocorticoid, spironolactone (SC 9420), and was not elicited either by a glucocorticoid, cortisol, or by the inactive isomer, 17-alpha-isoaldosterone. These findings are in accord with the inference that mRNA is induced by aldosterone during the latent period and that the induced mRNA mediates the action on sodium transport.
Mots-clé
Aldosterone/analogs & derivatives/*pharmacology
Aldosterone Antagonists
Animals
Anura
Biological Transport, Active/drug effects
Bufo marinus
Carbon Radioisotopes
Epithelium/metabolism
Female
Hydrocortisone/pharmacology
Kinetics
Methionine/metabolism
RNA/*biosynthesis
RNA, Messenger/biosynthesis
Sodium/metabolism
Spironolactone/pharmacology
Stimulation, Chemical
Tritium
Uridine/metabolism
Urinary Bladder/*metabolism
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 14:00
Dernière modification de la notice
20/08/2019 16:59