Differentiating Transient Idiopathic Hyperglycaemia and Neonatal Diabetes Mellitus in Preterm Infants.

Détails

ID Serval
serval:BIB_DA21B539BB3C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Differentiating Transient Idiopathic Hyperglycaemia and Neonatal Diabetes Mellitus in Preterm Infants.
Périodique
Hormone research in paediatrics
Auteur(s)
Busiah K. (co-premier), Auger J. (co-premier), Fauret-Amsellem A.L., Dahan S., Pouvreau N., Cavé H., Polak M., Mitanchez D.
ISSN
1663-2826 (Electronic)
ISSN-L
1663-2818
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
84
Numéro
1
Pages
68-72
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Transient idiopathic hyperglycaemia (TIH) is partly due to defective processing of proinsulin to insulin in preterm neonates, whereas transient neonatal diabetes mellitus (TNDM) is a rare genetic form of pancreatic β-cell dysfunction. Distinguishing these two conditions is difficult yet essential to allow personalised management and genetic testing. Here we investigated whether metabolic or therapeutic features contributed to the diagnosis in preterm neonates.
We prospectively included 13 preterm neonates with TIH between 2008 and 2011, and we identified 2 patients with TNDM in the French neonatal diabetes cohort registry. All of them were born before 32 weeks of gestation. We compared clinical features, glycaemic profiles, insulin dosages, and nutritional intakes.
TNDM patients had higher day-1 glycaemia levels before insulin therapy [median 23.5 (20-27) vs. 13.6 (10.7-19.8) mmol/l, p = 0.025] and higher insulin requirements [median 1.2 (0.9-1.5) vs. 0.8 (0.3-0.9) IU/kg/day, p = 0.037] compared to TIH. They also required insulin therapy earlier [median 0.75 (0.5-1) vs. 2 (0.5-7) days, p = 0.036] and for a longer time [median 85 (57-113) vs. 11 (4-15) days, p = 0.036].
TNDM and TIH are different clinical and genetic entities with specific pathophysiological mechanisms. Metabolic and therapeutic features may help to detect TNDM in preterm neonates as soon as day-1 of hyperglycaemia.
Mots-clé
Diabetes Mellitus/blood, Diabetes Mellitus/diagnosis, Diabetes Mellitus/drug therapy, Diabetes Mellitus/genetics, Female, Humans, Hyperglycemia/blood, Hyperglycemia/diagnosis, Hyperglycemia/drug therapy, Hyperglycemia/genetics, Infant, Newborn, Infant, Premature, Infant, Premature, Diseases/blood, Infant, Premature, Diseases/diagnosis, Infant, Premature, Diseases/drug therapy, Infant, Premature, Diseases/genetics, Insulin/administration & dosage, Male, Prospective Studies, Registries
Pubmed
Web of science
Création de la notice
28/02/2020 16:07
Dernière modification de la notice
26/03/2020 6:26
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