Electrical stimulation induces propagated colonic contractions in an experimental model.

Détails

ID Serval
serval:BIB_DA1BBB570E13
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Electrical stimulation induces propagated colonic contractions in an experimental model.
Périodique
The British Journal of Surgery
Auteur(s)
Aellen S., Wiesel P.H., Gardaz J.P., Schlageter V., Bertschi M., Virag N., Givel J.C.
ISSN
1365-2168[electronic]
Statut éditorial
Publié
Date de publication
2009
Volume
96
Numéro
2
Pages
214-220
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
BACKGROUND: Direct colonic electrical stimulation may prove to be a treatment option for specific motility disorders such as chronic constipation. The aim of this study was to provoke colonic contractions using electrical stimulation delivered from a battery-operated device. METHODS: Electrodes were inserted into the caecal seromuscular layer of eight anaesthetized pigs. Contractions were induced by a neurostimulator (Medtronic 3625). Caecal motility was measured simultaneously by video image analysis, manometry and a technique assessing colonic transit. RESULTS: Caecal contractions were generated using 8-10 V amplitude, 1000 micros pulse width, 120 Hz frequency for 10-30 s, with an intensity of 7-15 mA. The maximal contraction strength was observed after 20-25 s. Electrical stimulation was followed by a relaxation phase of 1.5-2 min during which contractions propagated orally and aborally over at least 10 cm. Spontaneous and stimulated caecal motility values were significantly different for both intraluminal pressure (mean(s.d.) 332(124) and 463(187) mmHg respectively; P < 0.001, 42 experiments) and movement of contents (1.6(0.9) and 3.9(2.8) mm; P < 0.001, 40 experiments). CONCLUSION: Electrical stimulation modulated caecal motility, and provoked localized and propagated colonic contractions.
Mots-clé
Animals, Cecum/physiology, Colon/physiology, Electric Stimulation, Electrodes, Gastrointestinal Motility/physiology, Muscle Contraction/physiology, Pressure, Swine
Pubmed
Web of science
Création de la notice
01/02/2010 13:41
Dernière modification de la notice
20/08/2019 15:59
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