Processing and presentation of tetanus toxin by antigen-presenting cells from patients with chronic granulomatous disease (CGD) to human specific T cell clones are not impaired

Détails

ID Serval
serval:BIB_DA13657D064C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Processing and presentation of tetanus toxin by antigen-presenting cells from patients with chronic granulomatous disease (CGD) to human specific T cell clones are not impaired
Périodique
Clinical and Experimental Immunology
Auteur(s)
Barbey  C., Tiercy  J. M., Fairweather  N., Niemann  H., Seger  R., Corradin  G.
ISSN
0009-9104 (Print)
Statut éditorial
Publié
Date de publication
02/1994
Volume
95
Numéro
2
Pages
227-31
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Feb
Résumé
The capacity of peripheral blood lymphocytes (PBL) or Epstein-Barr virus (EBV)-transformed B cell lines from CGD patients to process and present tetanus toxin (tt)-specific epitopes was assessed using various tt preparations and human tt-specific T cell clones. PBL from all of the donors were able to process and present either native tt and/or denatured tt to human T cell clones specific for various tt epitopes. Furthermore, no difference was found in the antigen requirement when normal or CGD EBV-B cell lines were used as antigen-presenting cells (APC). These results suggest that the deficiency in oxygen metabolism in CGD cells does not affect tt processing and presentation.
Mots-clé
Amino Acid Sequence *Antigen Presentation Antigen-Presenting Cells/*physiology B-Lymphocytes/physiology Cell Line, Transformed Clone Cells Granulomatous Disease, Chronic/*immunology Herpesvirus 4, Human Histocompatibility Antigens Class II/analysis Humans Molecular Sequence Data T-Lymphocytes/*immunology Tetanus Toxin/*immunology
Pubmed
Web of science
Création de la notice
24/01/2008 14:55
Dernière modification de la notice
20/08/2019 15:59
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