Presence of genetic alterations in microdissected stroma of human colon and breast cancers.

Détails

ID Serval
serval:BIB_DA02BD975784
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Presence of genetic alterations in microdissected stroma of human colon and breast cancers.
Périodique
Anticancer research
Auteur(s)
Wernert N., Löcherbach C., Wellmann A., Behrens P., Hügel A.
ISSN
0250-7005
Statut éditorial
Publié
Date de publication
2001
Peer-reviewed
Oui
Volume
21
Numéro
4A
Pages
2259-2264
Langue
anglais
Notes
Publication types: Journal Article ; Research Support
Résumé
BACKGROUND: Human carcinomas not only consist of neoplastic epithelial cells but also of tumor stroma, which may play an important role in tumor-progression. Whereas the tumor surrounding stroma is generally believed to represent a reactive component induced by tumor cell derived factors, a contribution of neoplastic cells to stroma formation via epithelium-mesenchyme transition during tumor invasion has become a novel concept in recent years. MATERIALS, METHODS AND RESULTS: We here show, by laser-assisted microdissection, that frequent genetic alterations in non-hereditary invasive human colon and breast cancers (loss of heterozygosity and TP53 mutations) occur not only in the neoplastic epithelial cells, but also in the adjacent fibroblastic stroma and that both components can share clonal features. CONCLUSION: Tumor cell-mesenchyme transitions are among the possible explanations for these findings and could actually occur during tumor invasion in vivo.
Mots-clé
Breast Neoplasms/genetics, Breast Neoplasms/pathology, Carcinoma, Ductal, Breast/genetics, Carcinoma, Ductal, Breast/pathology, Colonic Neoplasms/genetics, Colonic Neoplasms/pathology, Dissection, Genes, p53/genetics, Humans, Loss of Heterozygosity, Microsatellite Repeats/genetics, Mutation, Stromal Cells/pathology, Stromal Cells/physiology
Pubmed
Web of science
Création de la notice
27/02/2008 16:48
Dernière modification de la notice
20/08/2019 15:59
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