A quorum sensing regulated small volatile molecule reduces acute virulence and promotes chronic infection phenotypes.

Détails

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Etat: Public
Version: Final published version
ID Serval
serval:BIB_D9DBE50FB3DE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
A quorum sensing regulated small volatile molecule reduces acute virulence and promotes chronic infection phenotypes.
Périodique
Plos Pathogens
Auteur(s)
Kesarwani M., Hazan R., He J., Que YA., Apidianakis Y., Lesic B., Xiao G., Dekimpe V., Milot S., Deziel E., Lépine F., Rahme L.G.
ISSN
1553-7374 (Electronic)
ISSN-L
1553-7366
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
7
Numéro
8
Pages
e1002192
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
A significant number of environmental microorganisms can cause serious, even fatal, acute and chronic infections in humans. The severity and outcome of each type of infection depends on the expression of specific bacterial phenotypes controlled by complex regulatory networks that sense and respond to the host environment. Although bacterial signals that contribute to a successful acute infection have been identified in a number of pathogens, the signals that mediate the onset and establishment of chronic infections have yet to be discovered. We identified a volatile, low molecular weight molecule, 2-amino acetophenone (2-AA), produced by the opportunistic human pathogen Pseudomonas aeruginosa that reduces bacterial virulence in vivo in flies and in an acute mouse infection model. 2-AA modulates the activity of the virulence regulator MvfR (multiple virulence factor regulator) via a negative feedback loop and it promotes the emergence of P. aeruginosa phenotypes that likely promote chronic lung infections, including accumulation of lasR mutants, long-term survival at stationary phase, and persistence in a Drosophila infection model. We report for the first time the existence of a quorum sensing (QS) regulated volatile molecule that induces bistability phenotype by stochastically silencing acute virulence functions in P. aeruginosa. We propose that 2-AA mediates changes in a subpopulation of cells that facilitate the exploitation of dynamic host environments and promote gene expression changes that favor chronic infections.
Pubmed
Web of science
Open Access
Oui
Création de la notice
01/11/2011 11:11
Dernière modification de la notice
20/08/2019 15:59
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