Bile acids and gene regulation: from nuclear receptors to chromatin.

Détails

ID Serval
serval:BIB_D9C42F4DF4D7
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Bile acids and gene regulation: from nuclear receptors to chromatin.
Périodique
Frontiers in bioscience
Auteur(s)
Mitro N., Gilardi F., Godio C., Scotti E., De Fabiani E., Caruso D., Crestani M.
ISSN
1093-9946 (Print)
ISSN-L
1093-4715
Statut éditorial
Publié
Date de publication
01/05/2008
Peer-reviewed
Oui
Volume
13
Pages
6276-6288
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: epublish
Résumé
Transcription regulation by bile acids is far more complicated than it appeared at first when several groups began their investigations in the early '90. It has become clear now that bile acids regulate the transcription of genes involved in bile acid synthesis, transport and other metabolic pathways via multiple mechanisms that involve transcription factors, nuclear receptors, coregulators, chromatin and the related modifying enzyme complexes. At a first look this might seem surprising but if one considers the physical-chemical properties of these molecules it should be evident that, due to their detergent properties, bile acids may be harmful if they reach high concentrations in the liver and intestine. Therefore, living organisms have developed biochemical mechanisms that finely tune the concentration of bile acids according to the body needs and in response to environmental challenges. In this review, we will discuss the most recent evidences on the mechanisms through which bile acids regulate gene transcription, including the function of nuclear receptors and emphasizing the emerging role of chromatin and the associated modifying enzymes.
Mots-clé
Animals, Bile Acids and Salts/pharmacology, Cholesterol 7-alpha-Hydroxylase/drug effects, Cholesterol 7-alpha-Hydroxylase/genetics, Chromatin/drug effects, Chromatin/physiology, DNA-Binding Proteins/drug effects, DNA-Binding Proteins/genetics, Gene Expression Regulation/drug effects, Humans, Mice, Receptors, Cytoplasmic and Nuclear/drug effects, Receptors, Cytoplasmic and Nuclear/genetics, Receptors, Cytoplasmic and Nuclear/physiology, Transcription Factors/drug effects, Transcription Factors/genetics, Transcription, Genetic/drug effects
Pubmed
Web of science
Création de la notice
21/03/2019 11:29
Dernière modification de la notice
20/02/2020 6:26
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