Negative socio-emotional resonance in schizophrenia : a functional magnetic resonance imaging hypothesis

Détails

ID Serval
serval:BIB_D9A4A8709ABF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Negative socio-emotional resonance in schizophrenia : a functional magnetic resonance imaging hypothesis
Périodique
Medical hypotheses
Auteur⸱e⸱s
Fahim C., Stip E., Mancini-Marïe A., Boualem M., Malaspina D., Beauregard M.
ISSN
0306-9877
Statut éditorial
Publié
Date de publication
2004
Volume
63
Numéro
3
Pages
467-75
Langue
anglais
Notes
Publication types: Clinical Trial ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Résumé
The aim of the present study is to use neuroscience theories about brain function (mirror-neurons MN) to draw inferences about the mechanisms supporting emotional resonance in two different groups of schizophrenia patients (with flat affect FA+ n = 13 and without flat affect FA- n = 11). We hypothesize that FA+ will not activate key brain areas involved in emotional processing. Conversely, FA- will have a functional mirror system for emotional resonance confirmed by activation of the prefrontal cortex and behavioral results. To test this hypothesis, we compared the two groups using blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) displaying a passive visual task (44 negative IAPS pictures and 44 neutral pictures). A random-effects analysis, for schizophrenia patients FA-, revealed significant loci of activation in the left mesial prefrontal (MPFC), right orbitofrontal (OFC) and left anterior cingulate cortices (ACC). Correlational analyses carried out between self-report ratings of negative feelings and BOLD signal changes revealed the existence of positive correlation in the LACC, LMPFC and ROFC. Conversely, FA+ did not show significant activation in the prefrontal cortex. We propose that negative emotional resonance induced by passively viewing negative pictures may be a form of "mirroring" that grounds negative feelings via an experiential mechanism. Hence, it could be argued that FA- were able to 'feel' emotions through this resonance behavior. Conversely, we suggest that the dysfunction seen in the FA+ group is a failure or distortion in the development of the MN system. This could be due to genetic or other endogenous causes, which affected prefrontal cortex MN involved in emotional resonance.
Mots-clé
Adult, Affect, Brain Mapping / methods, Emotions, Female, Humans, Magnetic Resonance Imaging / methods, Male, Middle Aged, Prefrontal Cortex / physiopathology, Schizophrenia / classification, Schizophrenia / diagnosis, Schizophrenic Psychology, Self Concept, Social Behavior
Pubmed
Création de la notice
24/06/2009 13:41
Dernière modification de la notice
20/08/2019 15:58
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