Association between resistin levels and cardiovascular disease events in older adults: The health, aging and body composition study.

Détails

ID Serval
serval:BIB_D8D81D0E137F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Association between resistin levels and cardiovascular disease events in older adults: The health, aging and body composition study.
Périodique
Atherosclerosis
Auteur⸱e⸱s
Gencer B., Auer R., de Rekeneire N., Butler J., Kalogeropoulos A., Bauer D.C., Kritchevsky S.B., Miljkovic I., Vittinghoff E., Harris T., Rodondi N.
ISSN
1879-1484 (Electronic)
ISSN-L
0021-9150
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
245
Pages
181-186
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
OBJECTIVE: Prospective data on the association between resistin levels and cardiovascular disease (CVD) events are sparse with conflicting results.
METHODS: We studied 3044 aged 70-79 years from the Health, Aging, and Body Composition Study. CVD events were defined as coronary heart disease (CHD) or stroke events. «Hard » CHD events were defined as CHD death or myocardial infarction. We estimated hazard ratio (HR) and 95% confidence intervals (CI) according to the quartiles of serum resistin concentrations and adjusted for clinical variables, and then further adjusted for metabolic disease (body mass index, fasting plasma glucose, abdominal visceral and subcutaneous adipose tissue, leptin, adiponectin, insulin) and inflammation (C-reactive protein, interleukin-6, tumor necrosis factors-α).
RESULTS: During a median follow-up of 10.1 years, 559 patients had « hard » CHD events, 884 CHD events and 1106 CVD Events. Unadjusted incidence rate for CVD events was 36.6 (95% CI 32.1-41.1) per 1000 persons-year in the lowest quartile and 54.0 per 1000 persons-year in the highest quartile (95% CI 48.2-59.8, P for trend < 0.001). In the multivariate models adjusted for clinical variables, HRs for the highest vs. lowest quartile of resistin was 1.52 (95% CI 1.20-1.93, P < 0.001) for « Hard » CHD events, 1.41 (95% CI 1.16-1.70, P = 0.001) for CHD events and 1.35 (95% CI 1.14-1.59, P = 0.002) for CVD events. Further adjustment for metabolic disease slightly reduced the associations while adjustment for inflammation markedly reduced the associations.
CONCLUSIONS: In older adults, higher resistin levels are associated with CVD events independently of clinical risk factors and metabolic disease markers, but markedly attenuated by inflammation.
Mots-clé
Aged, Aging, Body Composition, Cardiovascular Diseases/blood, Cardiovascular Diseases/epidemiology, Female, Forecasting, Humans, Incidence, Male, Prospective Studies, Resistin/blood, Risk Factors, United States/epidemiology
Pubmed
Web of science
Création de la notice
19/02/2016 19:51
Dernière modification de la notice
20/08/2019 15:58
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