Anisoylated plasminogen streptokinase activator complex versus streptokinase in acute myocardial infarction. Preliminary results of a randomised study.

Détails

ID Serval
serval:BIB_D8B36A3E1AE9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Anisoylated plasminogen streptokinase activator complex versus streptokinase in acute myocardial infarction. Preliminary results of a randomised study.
Périodique
Drugs
Auteur(s)
Monnier P., Sigwart U., Vincent A., Bachmann F., Goy J.J., Schaller M.D., Kaufmann U., Badan M., Grbic M., Perret C., Kappenberger L.
ISSN
0012-6667 (Print)
ISSN-L
0012-6667
Statut éditorial
Publié
Date de publication
1987
Volume
33 Suppl 3
Pages
175-178
Langue
anglais
Notes
Publication types: Clinical Trial ; Comparative Study ; Journal Article ; Randomized Controlled Trial
Résumé
25 patients with acute myocardial infarction pain lasting more than 20 minutes which was not relieved by nitrates, whose ECGs showed ST segment elevations of 1 mm or more in 2 or more ECG leads, and who presented less than 3 hours after onset of their symptoms were randomly assigned to one of 2 thrombolytic treatment groups: a single intravenous bolus of anisoylated plasminogen streptokinase activator complex (APSAC) 30U in 5 minutes or an intravenous infusion of streptokinase 1,500,000U over 60 minutes. 3 to 4 hours after the administration of the thrombolytic agent, all patients received intravenous heparin at full dosage for 24 hours. The patency of the infarct-related coronary vessels was assessed by angiography 1 to 4 hours after administration of the thrombolytic agent. Clinical signs, ECGs, pulse, blood pressure and temperature were monitored regularly for 24 hours after treatment or as clinically appropriate. APSAC seemed to be at least as effective as streptokinase in terms of patency of the infarct-related vessel (92% vs 63%, respectively). The adverse events were similar and none was life-threatening. APSAC and streptokinase caused similar falls in blood fibrinogen levels. APSAC, given as a bolus injection over 5 minutes, was easier to administer than streptokinase, which was given as an infusion during 60 minutes.
Mots-clé
Adult, Aged, Anistreplase, Coronary Angiography, Female, Fibrinolytic Agents/therapeutic use, Humans, Infusions, Intravenous, Injections, Intravenous, Male, Middle Aged, Myocardial Infarction/drug therapy, Plasminogen/therapeutic use, Random Allocation, Streptokinase/therapeutic use
Pubmed
Web of science
Création de la notice
03/09/2011 20:14
Dernière modification de la notice
20/08/2019 15:58
Données d'usage