Can hTERT peptide (540-548) -specific CD8 T cells recognize and kill tumor cells?

Détails

ID Serval
serval:BIB_D859CE8A54F9
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Can hTERT peptide (540-548) -specific CD8 T cells recognize and kill tumor cells?
Périodique
Cancer Immunity
Auteur(s)
Speiser D.E., Cerottini J.C., Romero P.
ISSN
1424-9634[electronic], 1424-9634[linking]
Statut éditorial
Publié
Date de publication
2002
Volume
2
Pages
14
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Résumé
This commentary reviews the data on HLA-A2-restricted CD8 T cells specific for peptide (540-548) derived from hTERT (human telomerase reverse transcriptase). Several studies have reported the successful generation of such T cells (1, 2, 3). However, tumor recognition was observed in some, but not all, studies. More data are required to elucidate whether hTERT peptide (540-548) -specific T cells can indeed recognize and destroy tumor cells. It would be highly useful if telomerase would emerge as a universal tumor antigen that can be targeted in the cancer immunotherapy of HLA-A2 positive patients.
Mots-clé
CD8-Positive T-Lymphocytes/cytology, CD8-Positive T-Lymphocytes/immunology, Cytotoxicity, Immunologic, Humans, Neoplasms/enzymology, Neoplasms/immunology, Peptide Fragments/immunology, T-Lymphocytes, Cytotoxic/cytology, T-Lymphocytes, Cytotoxic/immunology, Telomerase/immunology
Pubmed
Création de la notice
28/01/2008 11:14
Dernière modification de la notice
20/08/2019 15:57
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