NKp30 isoforms and NKp46 transcripts in metastatic melanoma patients: Unique NKp30 pattern in rare melanoma patients with favorable evolution.

Détails

ID Serval
serval:BIB_D83B310AD17D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
NKp30 isoforms and NKp46 transcripts in metastatic melanoma patients: Unique NKp30 pattern in rare melanoma patients with favorable evolution.
Périodique
Oncoimmunology
Auteur(s)
Messaoudene M., Fregni G., Enot D., Jacquelot N., Neves E., Germaud N., Garchon H.J., Boukouaci W., Tamouza R., Chanal J., Avril M.F., Toubert A., Zitvogel L., Rusakiewicz S., Caignard A.
ISSN
2162-4011 (Print)
ISSN-L
2162-4011
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
5
Numéro
12
Pages
e1154251
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Given the NK cell-based immunosurveillance of melanoma, we investigated the prognostic value of NKp46 transcript and NKp30 isoform (NKp30A, NKp30B and NKp30C) profiling in blood of 187 melanoma patients including 13 long survivors (LS), metastatic patients that have controlled the disease. Compared to healthy volunteers (HV), patients had reduced amounts of transcripts of the three NKp30 isoforms (NKp30 A, B and C) but similar ratios between NKp30 isoforms (ΔAB, ΔAC, ΔBC). Stratification of patients according to disease stage showed higher NKp30C and lower NKp46 transcripts in stage IV patients. Furthermore, patients with previous history of conventional chemotherapy displayed reduced NKp30A transcripts. The expression levels of NKp30 isoforms failed to predict survival from sampling of patients, while NKp46 expression predicted melanoma outcome. LS patients displayed elevated NKp30A levels, accordingly high ΔAB and ΔBC ratios, and a unique pattern of rare allelic variants of NKp30 SNPs. Moreover, NK cells from LS displayed correlated NKp30/NKp46 membrane expression, high spontaneous and NKp30- or NKp46-triggered degranulation. These data outline the impact of NKp30 and NKp46 transcripts on melanoma evolution and identify unique genetic features of NKp30 associated with higher NK activation in rare LS melanoma patients that control a metastatic disease.

Pubmed
Web of science
Création de la notice
07/02/2017 19:38
Dernière modification de la notice
20/08/2019 16:57
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