GABA regulates dendritic growth by stabilizing lamellipodia in newly generated interneurons of the olfactory bulb.

Détails

ID Serval
serval:BIB_D7F310FCCB21
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
GABA regulates dendritic growth by stabilizing lamellipodia in newly generated interneurons of the olfactory bulb.
Périodique
The Journal of neuroscience
Auteur⸱e⸱s
Gascon E., Dayer A.G., Sauvain M.O., Potter G., Jenny B., De Roo M., Zgraggen E., Demaurex N., Muller D., Kiss J.Z.
ISSN
1529-2401 (Electronic)
ISSN-L
0270-6474
Statut éditorial
Publié
Date de publication
13/12/2006
Peer-reviewed
Oui
Volume
26
Numéro
50
Pages
12956-12966
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
The initial formation and growth of dendrites is a critical step leading to the integration of newly generated neurons into postnatal functional networks. However, the cellular mechanisms and extracellular signals regulating this process remain mostly unknown. By directly observing newborn neurons derived from the subventricular zone in culture as well as in olfactory bulb slices, we show that ambient GABA acting through GABA(A) receptors is essential for the temporal stability of lamellipodial protrusions in dendritic growth cones but did not interfere with filopodia dynamics. Furthermore, we provide direct evidence that ambient GABA is required for the proper initiation and elongation of dendrites by promoting the rapid stabilization of new dendritic segments after their extension. The effects of GABA on the initial formation of dendrites depend on depolarization and Ca2+ influx and are associated with a higher stability of microtubules. Together, our results indicate that ambient GABA is a key regulator of dendritic initiation in postnatally generated olfactory interneurons and offer a mechanism by which this neurotransmitter drives early dendritic growth.
Mots-clé
Animals, Animals, Newborn, Cells, Cultured, Dendrites/physiology, GABA-A Receptor Agonists, Growth Cones/physiology, Interneurons/physiology, Olfactory Bulb/growth & development, Pseudopodia/physiology, Rats, Rats, Sprague-Dawley, Receptors, GABA-A/physiology, gamma-Aminobutyric Acid/physiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
19/03/2021 14:45
Dernière modification de la notice
20/03/2021 6:26
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