T memory stem cells in health and disease.

Détails

ID Serval
serval:BIB_D7CE18B9CA28
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
T memory stem cells in health and disease.
Périodique
Nature medicine
Auteur⸱e⸱s
Gattinoni L., Speiser D.E., Lichterfeld M., Bonini C.
ISSN
1546-170X (Electronic)
ISSN-L
1078-8956
Statut éditorial
Publié
Date de publication
06/01/2017
Peer-reviewed
Oui
Volume
23
Numéro
1
Pages
18-27
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
T memory stem (TSCM) cells are a rare subset of memory lymphocytes endowed with the stem cell-like ability to self-renew and the multipotent capacity to reconstitute the entire spectrum of memory and effector T cell subsets. Cumulative evidence in mice, nonhuman primates and humans indicates that TSCM cells are minimally differentiated cells at the apex of the hierarchical system of memory T lymphocytes. Here we describe emerging findings demonstrating that TSCM cells, owing to their extreme longevity and robust potential for immune reconstitution, are central players in many physiological and pathological human processes. We also discuss how TSCM cell stemness could be leveraged therapeutically to enhance the efficacy of vaccines and adoptive T cell therapies for cancer and infectious diseases or, conversely, how it could be disrupted to treat TSCM cell driven and sustained diseases, such as autoimmunity, adult T cell leukemia and HIV-1.

Mots-clé
Adoptive Transfer, Animals, Autoimmune Diseases/immunology, Autoimmune Diseases/therapy, Cell Differentiation, Cell Self Renewal/immunology, HIV Infections/immunology, HIV Infections/therapy, Humans, Immunologic Memory/immunology, Leukemia, T-Cell/immunology, Leukemia, T-Cell/therapy, Stem Cells/immunology, T-Lymphocytes/immunology, T-Lymphocytes/transplantation
Pubmed
Web of science
Création de la notice
17/01/2017 19:06
Dernière modification de la notice
20/08/2019 15:57
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