Suprasellar chordoid neoplasm with expression of thyroid transcription factor 1: evidence that chordoid glioma of the third ventricle and pituicytoma may form part of a spectrum of lineage-related tumors of the basal forebrain.

Détails

ID Serval
serval:BIB_D7387C16D2FC
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Suprasellar chordoid neoplasm with expression of thyroid transcription factor 1: evidence that chordoid glioma of the third ventricle and pituicytoma may form part of a spectrum of lineage-related tumors of the basal forebrain.
Périodique
Human pathology
Auteur(s)
Hewer E., Beck J., Kellner-Weldon F., Vajtai I.
ISSN
1532-8392 (Electronic)
ISSN-L
0046-8177
Statut éditorial
Publié
Date de publication
07/2015
Peer-reviewed
Oui
Volume
46
Numéro
7
Pages
1045-1049
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Résumé
Chordoid glioma of the third ventricle is a rare neuroepithelial tumor characterized by a unique histomorphology and exclusive association with the suprasellar/third ventricular compartment. Variously interpreted as either astrocytic- or ependymal-like, and speculatively ascribed to the lamina terminalis/subcommissural organ, its histogenesis remains, nevertheless, unsettled. Here, we report on a suprasellar chordoid glioma occurring in a 52-year-old man. Although displaying otherwise typical morphological features, the tumor was notable for expression of thyroid transcription factor 1, a marker of tumors of pituicytic origin in the context of the sellar region. We furthermore found overlapping immunoprofiles of this example of chordoid glioma and pituicytic tumors (pituicytoma and spindle cell oncocytoma), respectively. Specifically, phosphorylated ribosomal protein S6, a marker of mTOR pathway activation, was expressed in both groups. Based on these findings, we suggest that chordoid glioma and pituicytic tumors may form part of a spectrum of lineage-related neoplasms of the basal forebrain.
Mots-clé
Adenoma, Oxyphilic/chemistry, Adenoma, Oxyphilic/pathology, Biomarkers, Tumor/analysis, Cell Lineage, Cerebral Ventricle Neoplasms/chemistry, Cerebral Ventricle Neoplasms/pathology, Cerebral Ventricle Neoplasms/surgery, Glioma/chemistry, Glioma/pathology, Glioma/surgery, Humans, Immunohistochemistry, Immunophenotyping, Magnetic Resonance Imaging, Male, Middle Aged, Nuclear Proteins/analysis, Phosphorylation, Pituitary Neoplasms/chemistry, Pituitary Neoplasms/pathology, Predictive Value of Tests, Ribosomal Protein S6/analysis, Thyroid Nuclear Factor 1, Tissue Array Analysis, Transcription Factors/analysis, Chordoid glioma of the third ventricle, Histogenesis, Mammalian target of rapamycin, Pituicytoma, Spindle cell oncocytoma of the adenohypophysis, Thyroid transcription factor 1
Pubmed
Web of science
Création de la notice
31/08/2020 12:02
Dernière modification de la notice
10/11/2020 6:26
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