IL28B polymorphisms predict response to therapy among chronic hepatitis C patients with HCV genotype 4.

Détails

ID Serval
serval:BIB_D7055B294A41
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
IL28B polymorphisms predict response to therapy among chronic hepatitis C patients with HCV genotype 4.
Périodique
Journal of Viral Hepatitis
Auteur⸱e⸱s
Antaki N., Bibert S., Kebbewar K., Asaad F., Baroudi O., Alideeb S., Hadad M., Abboud D., Sabah H., Bochud P.Y., Negro F.
ISSN
1365-2893 (Electronic)
ISSN-L
1352-0504
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
20
Numéro
1
Pages
59-64
Langue
anglais
Notes
Publication types: JOURNAL ARTICLE
Résumé
Summary.  Genetic polymorphisms near IL28B are associated with spontaneous and treatment-induced clearance of hepatitis C virus (HCV). Our objective was to assess the predictive value of IL28B polymorphisms in the treatment of chronic hepatitis C of patients with HCV genotypes 4, for which data are currently limited. We analysed the association of IL28B polymorphisms with the virological response to treatment among 182 naïve chronic hepatitis C patients with HCV genotype 4, all from Syria. Associations of alleles with the response patterns were evaluated by univariate analysis and multivariate logistic regression, accounting for all relevant covariates. Sustained virological response (SVR) was achieved in 26% of rs8099917 TG/GG carriers compared with 60% of TT carriers (P < 0.0001) and 35% of rs12979860 CT/TT carriers compared with 62% of CC carriers (P = 0.0011). By multivariate analysis, the association between rs8099917 and SVR remained significant (OR = 0.19, 95% CI 0.07-0.50, for TG/GG vs TT, P = 0.0007), with the only significant covariate being advanced fibrosis (OR = 0.13, 95% CI 0.04-0.37, P = 0.0002). In conclusion, IL28B polymorphisms are the strongest predictors of response to therapy among chronic hepatitis C patients with HCV genotype 4.
Pubmed
Web of science
Création de la notice
10/01/2013 19:03
Dernière modification de la notice
20/08/2019 16:56
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