Cell type-specific structural plasticity of axonal branches and boutons in the adult neocortex

Détails

ID Serval
serval:BIB_D6D273D0C8B1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Cell type-specific structural plasticity of axonal branches and boutons in the adult neocortex
Périodique
Neuron
Auteur⸱e⸱s
De Paola  V., Holtmaat  A., Knott  G., Song  S., Wilbrecht  L., Caroni  P., Svoboda  K.
ISSN
0896-6273 (Print)
Statut éditorial
Publié
Date de publication
03/2006
Volume
49
Numéro
6
Pages
861-75
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar 16
Résumé
We imaged axons in layer (L) 1 of the mouse barrel cortex in vivo. Axons from thalamus and L2/3/5, or L6 pyramidal cells were identified based on their distinct morphologies. Their branching patterns and sizes were stable over times of months. However, axonal branches and boutons displayed cell type-specific rearrangements. Structural plasticity in thalamocortical afferents was mostly due to elongation and retraction of branches (range, 1-150 microm over 4 days; approximately 5% of total axonal length), while the majority of boutons persisted for up to 9 months (persistence over 1 month approximately 85%). In contrast, L6 axon terminaux boutons were highly plastic (persistence over 1 month approximately 40 %), and other intracortical axon boutons showed intermediate levels of plasticity. Retrospective electron microscopy revealed that new boutons make synapses. Our data suggest that structural plasticity of axonal branches and boutons contributes to the remodeling of specific functional circuits.
Mots-clé
Analysis of Variance Animals Antigens, Thy-1/genetics Diagnostic Imaging/methods Green Fluorescent Proteins/genetics Imaging, Three-Dimensional/methods Male Mice Mice, Inbred C57BL Mice, Transgenic Microscopy, Electron, Transmission/methods Models, Anatomic Models, Biological Neocortex/*cytology/ultrastructure *Neurites/ultrastructure Neuronal Plasticity/*physiology Neurons/*classification/*cytology/ultrastructure *Presynaptic Terminals/ultrastructure Time Factors
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 14:26
Dernière modification de la notice
20/08/2019 15:56
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