Effect of cetirizine in a conjunctival provocation test with allergens

Détails

ID Serval
serval:BIB_D6CE8938D9F8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Effect of cetirizine in a conjunctival provocation test with allergens
Périodique
Clinical and Experimental Allergy
Auteur⸱e⸱s
Schoeneich  M., Pecoud  A. R.
ISSN
0954-7894 (Print)
Statut éditorial
Publié
Date de publication
03/1990
Volume
20
Numéro
2
Pages
171-4
Notes
Clinical Trial
Controlled Clinical Trial
Journal Article
Randomized Controlled Trial --- Old month value: Mar
Résumé
Cetirizine is a new selective H1-antagonist. In a double-blind and placebo-controlled study, 11 subjects underwent a conjunctival provocation test (CPT) with a grass pollen extract to determine the effect of cetirizine on allergen-induced itching and redness of the eye. Results of CPTs were reproducible, as no difference was observed between the CPTs performed without any pre-treatment and the CPTs after placebo. Compared to placebo, cetirizine administered orally (10 mg twice a day for 4 days) and in double-blind fashion increased the conjunctival reaction threshold (P less than 0.004) by inhibiting both redness and itching of the eye. Cetirizine should protect patients against allergic conjunctivitis.
Mots-clé
Adolescent Adult Allergens/*administration & dosage Cetirizine Clinical Trials Conjunctivitis, Allergic/diagnosis/*drug therapy/etiology Double-Blind Method Female Histamine H1 Antagonists/therapeutic use Humans Hydroxyzine/*analogs & derivatives/therapeutic use Immunologic Tests Male Pollen/immunology Rhinitis, Allergic, Seasonal/diagnosis/drug therapy/etiology
Pubmed
Web of science
Création de la notice
28/01/2008 11:58
Dernière modification de la notice
20/08/2019 15:56
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