Assessment of the role of LASER-Doppler in the treatment of port-wine stains in infants.

Détails

ID Serval
serval:BIB_D696F3D5CB56
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Assessment of the role of LASER-Doppler in the treatment of port-wine stains in infants.
Périodique
Journal of Pediatric Surgery
Auteur⸱e⸱s
Mermod T., El Ezzi O., Raffoul W., Erba P., de Buys Roessingh A.
ISSN
1531-5037 (Electronic)
ISSN-L
0022-3468
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
50
Numéro
8
Pages
1388-1392
Langue
anglais
Notes
Publication types: Clinical Trial ; Journal Article
Publication Status: ppublish
Résumé
BACKGROUND: Port-wine stains (PWS) are malformations of capillaries in 0.3% of newborn children. The treatment of choice is by pulsed dye LASER (PDL), and requires several sessions. The efficacy of this treatment is at present evaluated on the basis of clinical inspection and of digital photographs taken throughout the treatment. LASER-Doppler imaging (LDI) is a noninvasive method of imaging the perfusion of the tissues by the microcirculatory system (capillaries). The aim of this paper is to demonstrate that LDI allows a quantitative, numerical evaluation of the efficacy of the PDL treatment of PWS.
METHOD: The PDL sessions were organized according to the usual scheme, every other month, from September 1, 2012, to September 30, 2013. LDI imaging was performed at the start and at the conclusion of the PDL treatment, and simultaneously on healthy skin in order to obtain reference values. The results evidenced by LDI were analyzed according to the "Wilcoxon signed-rank" test before and after each session, and in the intervals between the three PDL treatment sessions.
RESULTS: Our prospective study is based on 20 new children. On average, the vascularization of the PWS was reduced by 56% after three laser sessions. Compared with healthy skin, initial vascularization of PWS was 62% higher than that of healthy skin at the start of treatment, and 6% higher after three sessions. During the 2 months between two sessions, vascularization of the capillary network increased by 27%.
CONCLUSION: This study shows that LDI can demonstrate and measure the efficacy of PDL treatment of PWS in children. The figures obtained when measuring the results by LDI corroborate the clinical assessments and may allow us to refine, and perhaps even modify, our present use of PDL and thus improve the efficacy of the treatment.
Mots-clé
Child, Child, Preschool, Female, Humans, Infant, Laser-Doppler Flowmetry, Lasers, Dye/therapeutic use, Male, Microcirculation, Port-Wine Stain/physiopathology, Port-Wine Stain/therapy, Prospective Studies, Treatment Outcome
Pubmed
Web of science
Création de la notice
22/09/2015 17:33
Dernière modification de la notice
20/08/2019 16:56
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