Secreted proteases from pathogenic fungi

Détails

ID Serval
serval:BIB_D68E3A1A019F
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Secreted proteases from pathogenic fungi
Périodique
International Journal of Medical Microbiology
Auteur⸱e⸱s
Monod  M., Capoccia  S., Lechenne  B., Zaugg  C., Holdom  M., Jousson  O.
ISSN
1438-4221 (Print)
Statut éditorial
Publié
Date de publication
10/2002
Volume
292
Numéro
5-6
Pages
405-19
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Oct
Résumé
Many species of human pathogenic fungi secrete proteases in vitro or during the infection process. Secreted endoproteases belong to the aspartic proteases of the pepsin family, serine proteases of the subtilisin family, and metalloproteases of two different families. To these proteases has to be added the non-pepsin-type aspartic protease from Aspergillus niger and a unique chymotrypsin-like protease from Coccidioides immitis. Pathogenic fungi also secrete aminopeptidases, carboxypeptidases and dipeptidyl-peptidases. The function of fungal secreted proteases and their importance in infections vary. It is evident that secreted proteases are important for the virulence of dermatophytes since these fungi grow exclusively in the stratum corneum, nails or hair, which constitutes their sole nitrogen and carbon sources. The aspartic proteases secreted by Candida albicans are involved in the adherence process and penetration of tissues, and in interactions with the immune system of the infected host. For Aspergillus fumigatus, the role of proteolytic activity has not yet been proved. Although the secreted proteases have been intensively investigated as potential virulence factors, knowledge on protease substrate specificities is rather poor and few studies have focused on the research of inhibitors. Knowledge of substrate specificities will increase our understanding about the action of each protease secreted by pathogenic fungi and will help to determine their contribution to virulence.
Mots-clé
Arthrodermataceae/enzymology/pathogenicity Aspartic Endopeptidases/metabolism/secretion Aspergillus fumigatus/enzymology/pathogenicity Candida/enzymology/pathogenicity Endopeptidases/metabolism/*secretion Exopeptidases/metabolism/secretion Fungi/*enzymology/pathogenicity Humans Metalloendopeptidases/metabolism/secretion Rhizopus/enzymology/pathogenicity Serine Endopeptidases/metabolism/secretion Substrate Specificity Virulence
Pubmed
Web of science
Création de la notice
25/01/2008 16:47
Dernière modification de la notice
20/08/2019 15:56
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