Aldosterone and cardiovascular risk.

Détails

ID Serval
serval:BIB_D67D5AAAEA92
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Aldosterone and cardiovascular risk.
Périodique
Current Hypertension Reports
Auteur(s)
Vogt Bruno, Burnier Michel
ISSN
1534-3111[electronic]
Statut éditorial
Publié
Date de publication
2009
Volume
11
Numéro
6
Pages
450-455
Langue
anglais
Résumé
Through its classic effects on sodium and potassium homeostasis, aldosterone, when produced in excess, is associated with the development of hypertension and hence with higher cardiovascular and renal risk. In recent years, experimental and epidemiologic data have suggested that aldosterone also may be linked to high cardiovascular risk independently of its effects on blood pressure. Thus, aldosterone has been associated with obesity and metabolic syndrome in selected populations, and these associations may further contribute to the higher cardiovascular risk of subjects with elevated aldosterone levels. Moreover, aldosterone has been reported to promote inflammation, oxidative stress, and fibrosis in a number of tissues. Clinical evidence indicates that patients with primary hyperaldosteronism have a higher risk of developing cardiovascular and renal complications than patients with essential hypertension who have the same level of blood pressure. Aldosterone receptor blockade has been shown to lower cardiovascular mortality after myocardial infarction and in patients with congestive heart failure. Some studies have also demonstrated that aldosterone blockade could have a favorable impact on the progression of renal disease. However, prospective interventional trials are needed to further evaluate the impact of blockade of aldosterone on cardiovascular risk.
Mots-clé
Plasma-Renin Activity, Blood-Pressure, Metabolic Syndrome, Primary Hyperaldosteronism, Serum Aldosterone, Myocardial-Infarction, Heart-Failure, High-Salt, Hypertension, Insulin
Pubmed
Web of science
Création de la notice
15/12/2009 16:34
Dernière modification de la notice
20/08/2019 15:56
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