Technical note: Validation of an ultrahigh dose rate pulsed electron beam monitoring system using a current transformer for FLASH preclinical studies.

Détails

Ressource 1Télécharger: Medical Physics - 2022 - Gon alves Jorge - Technical note Validation of an ultrahigh dose rate pulsed electron beam.pdf (1942.07 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_D66CA0261E74
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Technical note: Validation of an ultrahigh dose rate pulsed electron beam monitoring system using a current transformer for FLASH preclinical studies.
Périodique
Medical physics
Auteur⸱e⸱s
Gonçalves Jorge P., Grilj V., Bourhis J., Vozenin M.C., Germond J.F., Bochud F., Bailat C., Moeckli R.
ISSN
2473-4209 (Electronic)
ISSN-L
0094-2405
Statut éditorial
Publié
Date de publication
03/2022
Peer-reviewed
Oui
Volume
49
Numéro
3
Pages
1831-1838
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
The Oriatron eRT6 is a linear accelerator (linac) used in FLASH preclinical studies able to reach dose rates ranging from conventional (CONV) up to ultrahigh (UHDR). This work describes the implementation of commercially available beam current transformers (BCTs) as online monitoring tools compatible with CONV and UHDR irradiations for preclinical FLASH studies.
Two BCTs were used to measure the output of the Oriatron eRT6 linac. First, the correspondence between the set nominal beam parameters and those measured by the BCTs was checked. Then, we established the relationship between the total exit charge (measured by BCTs) and the absorbed dose to water. The influence of the pulse width (PW) and the pulse repetition frequency (PRF) at UHDR was characterized, as well as the short- and long-term stabilities of the relationship between the exit charge and the dose at CONV and UHDR.
The BCTs were able to determine consistently the number of pulses, PW, and PRF. For fixed PW and pulse height, the exit charge measured from BCTs was correlated with the dose, and linear relationships were found with uncertainties of 0.5 % and 3 % in CONV and UHDR mode, respectively. Short- and long-term stabilities of the dose-to-charge ratio were below 1.6 %.
We implemented commercially available BCTs and demonstrated their ability to act as online beam monitoring systems to support FLASH preclinical studies with CONV and UHDR irradiations. The implemented BCTs support dosimetric measurements, highlight variations among multiple measurements in a row, enable monitoring of the physics parameters used for irradiation, and are an important step for the safety of the clinical translation of FLASH radiation therapy.
Mots-clé
Electrons, Particle Accelerators, Phantoms, Imaging, Radiometry, Radiotherapy Dosage, FLASH, beam current transformer, charge, dosimetry, monitoring, ultrahigh dose rate
Pubmed
Web of science
Open Access
Oui
Création de la notice
31/01/2022 11:47
Dernière modification de la notice
13/08/2022 7:14
Données d'usage