PET and SPECT functional imaging studies in Parkinsonian syndromes: from the lesion to its consequences.

Détails

ID Serval
serval:BIB_D60F8DA3821E
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
PET and SPECT functional imaging studies in Parkinsonian syndromes: from the lesion to its consequences.
Périodique
Neuroimage
Auteur(s)
Thobois S., Jahanshahi M., Pinto S., Frackowiak R., Limousin-Dowsey P.
ISSN
1053-8119 (Print)
ISSN-L
1053-8119
Statut éditorial
Publié
Date de publication
2004
Volume
23
Numéro
1
Pages
1-16
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; ReviewPublication Status: ppublish
Résumé
Functional imaging techniques provide major insights into understanding the pathophysiology, progression, complications, and differential diagnosis of Parkinson's disease (PD). The dopaminergic system has been particularly studied allowing now early, presymptomatic diagnoses, which is of interest for future neuroprotective strategies. The existence of a compensatory hyperactivity of dopa-decarboxylase at disease onset has been recently demonstrated in the nigrostriatal and also extrastriatal dopaminergic pathways. Modification of dopamine receptors expression is observed during PD, but the respective contribution of dopaminergic drugs and the disease process towards these changes is still debated. Abnormalities of cerebral activation are seen and are clearly task-dependent, but the coexistence of hypoactivation in some areas and hyperactivation in others is also now well established. Such hyperactivation may be compensatory but could also reflect an inability to select appropriate motor circuits and inhibit inappropriate ones by PD patients. Interestingly, dopaminergic medications or surgical therapy reverse such abnormalities of brain activation.
Mots-clé
Corpus Striatum/drug effects, Corpus Striatum/physiopathology, Dopamine/metabolism, Dopamine Agents/therapeutic use, Humans, Neural Pathways/drug effects, Neural Pathways/physiopathology, Parkinson Disease/drug therapy, Parkinson Disease/physiopathology, Positron-Emission Tomography, Receptors, Dopamine/drug effects, Receptors, Dopamine/physiology, Substantia Nigra/drug effects, Substantia Nigra/physiopathology, Tomography, Emission-Computed, Single-Photon
Pubmed
Web of science
Création de la notice
11/09/2011 19:29
Dernière modification de la notice
20/08/2019 16:55
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