Prevalence des anticorps seriques anti-virus de l'hepatite C et des facteurs de risque de contamination chez le personnel d'un hopital de la region parisienne. Une enquete prospective. [Prevalence of serum anti-hepatitis C virus antibodies and risk factors of contamination in the personnel of a hospital in the Paris region. A prospective survey]

Détails

ID Serval
serval:BIB_D5B7A441BE66
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Prevalence des anticorps seriques anti-virus de l'hepatite C et des facteurs de risque de contamination chez le personnel d'un hopital de la region parisienne. Une enquete prospective. [Prevalence of serum anti-hepatitis C virus antibodies and risk factors of contamination in the personnel of a hospital in the Paris region. A prospective survey]
Périodique
Gastroenterologie Clinique et Biologique
Auteur(s)
Maillard  M. F., Poynard  T., Dubreuil  P., Agostini  H., Hautecoeur  B., Pillot  J., Chaput  J. C.
ISSN
0399-8320 (Print)
Statut éditorial
Publié
Date de publication
1996
Volume
20
Numéro
12
Pages
1053-7
Notes
English Abstract
Journal Article
Research Support, Non-U.S. Gov't
Résumé
OBJECTIVES: The aim of this prospective study was to estimate the prevalence of subjects with serum anti-HCV antibodies in a University Hospital in the Paris area, and to identify the risk factors associated with contamination. METHODS: Over an 18 month period, each person working in the hospital was systematically requested to fill out an anonymous questionnaire including 23 questions and to undergo a blood test for an anti-HCV assay during their annual medical visit. RESULTS: 557 (33%) of 1693 employees accepted to fill out the questionnaire and the anti-HCV assay. Serum anti-HCV antibodies were present in 9 subjects, which represents a prevalence of 1.6%, and serum RNA was positive by PCR, m 7. The prevalence was significantly higher in subjects working in clinical units (3.0%) compared to subjects working in non-clinical units (0.7%: P = 0.04) and in subjects with a history of acute hepatitis (5.5% vs 0.9%; P = 0.002%) Anti-HCV-positive subjects had more history of manipulating blood products than HCV-negative subjects (17.0 vs 8.8 years of exposure; P = 0.01), other human samples (17.0 vs 7.6 years; P = 0.01), and of having at risk contacts (16.7 vs 6.2 years; P = 0.0004). CONCLUSION: These results suggest the importance of systematic anti-HCV screening among health care workers particularly those in contact with patients.
Mots-clé
Adult *Disease Transmission, Patient-to-Professional Enzyme-Linked Immunosorbent Assay Female Gene Amplification Hepatitis C/epidemiology/prevention & control/*transmission Hepatitis C Antibodies/*analysis Humans Male Paris *Personnel, Hospital Prevalence Prospective Studies Questionnaires Risk Factors
Pubmed
Web of science
Création de la notice
25/01/2008 13:59
Dernière modification de la notice
20/08/2019 16:55
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